Journal article
Mechanisms of lipotoxicity in the cardiovascular system
Current hypertension reports, Vol.14(6), pp.517-531
12/2012
DOI: 10.1007/s11906-012-0307-2
PMCID: PMC3491122
PMID: 23054891
Abstract
Cardiovascular diseases account for approximately one third of all deaths globally. Obese and diabetic patients have a high likelihood of dying from complications associated with cardiovascular dysfunction. Obesity and diabetes increase circulating lipids that upon tissue uptake, may be stored as triglyceride, or may be metabolized in other pathways, leading to the generation of toxic intermediates. Excess lipid utilization or activation of signaling pathways by lipid metabolites may disrupt cellular homeostasis and contribute to cell death, defining the concept of lipotoxicity. Lipotoxicity occurs in multiple organs, including cardiac and vascular tissues, and a number of specific mechanisms have been proposed to explain lipotoxic tissue injury. In addition, recent data suggests that increased tissue lipids may also be protective in certain contexts. This review will highlight recent progress toward elucidating the relationship between nutrient oversupply, lipotoxicity, and cardiovascular dysfunction. The review will focus in two sections on the vasculature and cardiomyocytes respectively.
Details
- Title: Subtitle
- Mechanisms of lipotoxicity in the cardiovascular system
- Creators
- Adam R Wende - Program in Molecular Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Utah School of Medicine, Salt Lake City, 84112, USAJ David SymonsE Dale Abel
- Resource Type
- Journal article
- Publication Details
- Current hypertension reports, Vol.14(6), pp.517-531
- DOI
- 10.1007/s11906-012-0307-2
- PMID
- 23054891
- PMCID
- PMC3491122
- NLM abbreviation
- Curr Hypertens Rep
- ISSN
- 1522-6417
- eISSN
- 1534-3111
- Publisher
- United States
- Grant note
- K99 HL111322 / NHLBI NIH HHS R15 HL091493 / NHLBI NIH HHS R01 HL108379 / NHLBI NIH HHS R01 DK092065 / NIDDK NIH HHS U01 HL087947 / NHLBI NIH HHS R01HL108379 / NHLBI NIH HHS
- Language
- English
- Date published
- 12/2012
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984025258302771
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