Journal article
Mechanisms of proteasome inhibitor-induced cytotoxicity in malignant glioma
Cell biology and toxicology, Vol.29(4), pp.199-211
08/01/2013
DOI: 10.1007/s10565-013-9248-z
PMID: 23733249
Abstract
The 26S proteasome constitutes an essential degradation apparatus involved in the consistent recycling of misfolded and damaged proteins inside cells. The aberrant activation of the proteasome has been widely observed in various types of cancers and implicated in the development and progression of carcinogenesis. In the era of targeted therapies, the clinical use of proteasome inhibitors necessitates a better understanding of the molecular mechanisms of cell death responsible for their cytotoxic action, which are reviewed here in the context of sensitization of malignant gliomas, a tumor type particularly refractory to conventional treatments.
Details
- Title: Subtitle
- Mechanisms of proteasome inhibitor-induced cytotoxicity in malignant glioma
- Creators
- Panagiotis J. Vlachostergios - University of ThessalyIoannis A. Voutsadakis - Charmo UniversityChristos N. Papandreou - University of Thessaly
- Resource Type
- Journal article
- Publication Details
- Cell biology and toxicology, Vol.29(4), pp.199-211
- Publisher
- Springer Nature
- DOI
- 10.1007/s10565-013-9248-z
- PMID
- 23733249
- ISSN
- 0742-2091
- eISSN
- 1573-6822
- Number of pages
- 13
- Language
- English
- Date published
- 08/01/2013
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984806606502771
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