Journal article
Mechanisms of thrombosis in hyperhomocysteinemia
Current opinion in hematology, Vol.5(5), pp.343-349
09/1998
DOI: 10.1097/00062752-199809000-00007
PMID: 9776214
Abstract
Hyperhomocysteinemia is now recognized as a common risk factor for thrombotic vascular events such as stroke, myocardial infarction, and venous thrombosis. Studies of cultured cells in vitro indicate that homocysteine has prothrombotic effects on the endothelium and vascular smooth muscle. An association between moderate hyperthomocysteinemia and vascular dysfunction was confirmed in recent studies in animals and humans. Current models propose that dysregulation of homocysteine metabolism may impair vascular function through mechanisms involving oxidant stress or altered cellular methylation. Although moderate hyperhomocysteinemia can be treated effectively by administration of folic acid and other B vitamins, the clinical benefit of this therapeutic approach has not been proven in patients with thrombosis.
Details
- Title: Subtitle
- Mechanisms of thrombosis in hyperhomocysteinemia
- Creators
- Steven Lentz - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Current opinion in hematology, Vol.5(5), pp.343-349
- Publisher
- Lippincott Williams & Wilkins, Inc
- DOI
- 10.1097/00062752-199809000-00007
- PMID
- 9776214
- ISSN
- 1065-6251
- eISSN
- 1531-7048
- Language
- English
- Date published
- 09/1998
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359898702771
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