Journal article
Mechanobiology and Resolution of Lung Fibrosis
Annual review of physiology, Vol.88(1), pp.487-511
02/2026
DOI: 10.1146/annurev-physiol-031725-021041
PMCID: PMC13003399
PMID: 41223415
Abstract
Pulmonary fibrosis is a devastating and progressive disease marked by replacement of gas-exchanging tissue with collagen-rich scar. The mechanical environment is profoundly altered in pulmonary fibrosis and contributes to disease progression via feedback relationships between cells, the extracellular matrix, and the evolving mechanical environment. Targeting these mechanobiological feedback loops has emerged as a promising approach to interrupt disease progression, though with challenges in how to intervene selectively, safely, and effectively. We posit that further delineation of cell-matrix mechanobiological interactions will be pivotal to promoting fibrosis resolution and should guide efforts to discover and implement new approaches that can preserve or even restore lung function. To set the stage for these advances, we first review the mechanobiology of the healthy lung and the feedback loops that promote fibrosis progression. We then lay out the challenges and opportunities for targeting the fibrotic matrix as an essential element for protecting or restoring lung function.
Details
- Title: Subtitle
- Mechanobiology and Resolution of Lung Fibrosis
- Creators
- Patrick A LinkDaniel J Tschumperlin
- Resource Type
- Journal article
- Publication Details
- Annual review of physiology, Vol.88(1), pp.487-511
- DOI
- 10.1146/annurev-physiol-031725-021041
- PMID
- 41223415
- PMCID
- PMC13003399
- NLM abbreviation
- Annu Rev Physiol
- ISSN
- 1545-1585
- eISSN
- 1545-1585
- Publisher
- ANNUAL REVIEWS
- Grant note
- US National Institutes of Health National Heart, Lung, and Blood Institute (NIH NHLBI): HL092961, HL166187, HL152967 US Department of Defense: CDMRP PRMRP HT9425-24-1-0208 Boehringer Ingelheim Fibrosis Discovery Award
The authors acknowledge support from the US National Institutes of Health National Heart, Lung, and Blood Institute (NIH NHLBI) grants HL092961, HL166187, and HL152967; the US Department of Defense (CDMRP PRMRP HT9425-24-1-0208); and a Boehringer Ingelheim Fibrosis Discovery Award.
- Language
- English
- Electronic publication date
- 11/12/2025
- Date published
- 02/2026
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Craniofacial Anomalies Research Center
- Record Identifier
- 9985032950702771
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