Journal article
Mechanochemistry Facilitates a Single-Crystal X-ray Structure Determination of Free Base Naloxone Anhydrate
Crystal growth & design, Vol.22(11), pp.6622-6626
10/17/2022
DOI: 10.1021/acs.cgd.2c00831
PMCID: PMC9634803
PMID: 36345388
Appears in UI Libraries Support Open Access
Abstract
A method to obtain single crystals of the opioid antagonist naloxone in the free base form is facilitated using mechanochemistry. The application of mechanochemistry reduces the number of steps and makes single crystals readily available from solution compared to using an approach based exclusively on solution or the reported method based on sublimation. The X-ray structure confirms the structure determined using powder diffraction and provides details of hydrogen bonding.
Details
- Title: Subtitle
- Mechanochemistry Facilitates a Single-Crystal X-ray Structure Determination of Free Base Naloxone Anhydrate
- Creators
- Celymar Ortiz-de Leon - Univ Iowa, Dept Chem, Iowa City, IA 52242 USAChristopher J. Hartwick - University of IowaClara A. Stuedemann - University of IowaNicole K. Brogden - University of IowaLeonard R. MacGillivray - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Crystal growth & design, Vol.22(11), pp.6622-6626
- DOI
- 10.1021/acs.cgd.2c00831
- PMID
- 36345388
- PMCID
- PMC9634803
- NLM abbreviation
- Cryst Growth Des
- ISSN
- 1528-7483
- eISSN
- 1528-7505
- Publisher
- American Chemical Society
- Number of pages
- 5
- Grant note
- DMR-2221086; DMR-1708673; CHE-1828117 / National Science Foundation; National Science Foundation (NSF) 1R35GM124551 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Consejo Nacional de Ciencia y Tecnologia; Consejo Nacional de Ciencia y Tecnologia (CONACyT)
- Language
- English
- Date published
- 10/17/2022
- Academic Unit
- Dermatology; Pharmaceutical Sciences and Experimental Therapeutics; Chemistry
- Record Identifier
- 9984361602302771
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