Journal article
Medial PFC Damage Abolishes the Self-reference Effect
Journal of cognitive neuroscience, Vol.24(2), pp.475-481
02/2012
DOI: 10.1162/jocn_a_00138
PMCID: PMC3297026
PMID: 21942762
Abstract
Functional neuroimaging studies suggest that the medial PFC (mPFC) is a key component of a large-scale neural system supporting a variety of self-related processes. However, it remains unknown whether the mPFC is critical for such processes. In this study, we used a human lesion approach to examine this question. We administered a standard trait judgment paradigm [Kelley, W. M., Macrae, C. N., Wyland, C. L., Caglar, S., Inati, S., & Heatherton, T. F. Finding the self? An event-related fMRI study.
Journal of Cognitive Neuroscience, 14,
785–794, 2002] to patients with focal brain damage to the mPFC. The self-reference effect (SRE), a memory advantage conferred by self-related processing, served as a measure of intact self-processing ability. We found that damage to the mPFC abolished the SRE. The results demonstrate that the mPFC is necessary for the SRE and suggest that this structure is important for self-referential processing and the neural representation of self.
Details
- Title: Subtitle
- Medial PFC Damage Abolishes the Self-reference Effect
- Creators
- Carissa L Philippi - University of IowaMelissa C Duff - University of IowaNatalie L Denburg - University of IowaDaniel Tranel - University of IowaDavid Rudrauf - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of cognitive neuroscience, Vol.24(2), pp.475-481
- DOI
- 10.1162/jocn_a_00138
- PMID
- 21942762
- PMCID
- PMC3297026
- NLM abbreviation
- J Cogn Neurosci
- ISSN
- 0898-929X
- eISSN
- 1530-8898
- Publisher
- MIT Press
- Language
- English
- Date published
- 02/2012
- Academic Unit
- Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984002493902771
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