Medial frontal ∼4-Hz activity in humans and rodents is attenuated in PD patients and in rodents with cortical dopamine depletion

Krystal L Parker; Kuan-Hua Chen; Johnathan R Kingyon; James F Cavanagh; Nandakumar S Narayanan

doi:10.1152/jn.00412.2015

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Medial frontal ∼4-Hz activity in humans and rodents is attenuated in PD patients and in rodents with cortical dopamine depletion

Journal article

Open access

Peer reviewed

Medial frontal ∼4-Hz activity in humans and rodents is attenuated in PD patients and in rodents with cortical dopamine depletion

Krystal L Parker, Kuan-Hua Chen, Johnathan R Kingyon, James F Cavanagh and Nandakumar S Narayanan

Journal of neurophysiology, Vol.114(2), pp.1310-1320

08/2015

DOI: 10.1152/jn.00412.2015

PMCID: PMC4588517

PMID: 26133799

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Abstract

The temporal control of action is a highly conserved and critical mammalian behavior. Here, we investigate the neuronal basis of this process using an interval timing task. In rats and humans, instructional timing cues triggered spectral power across delta and theta bands (2-6 Hz) from the medial frontal cortex (MFC). Humans and rodents with dysfunctional dopamine have impaired interval timing, and we found that both humans with Parkinson's disease (PD) and rodents with local MFC dopamine depletion had attenuated delta and theta activity. In rodents, spectral activity in this range could functionally couple single MFC neurons involved in temporal processing. Without MFC dopamine, these neurons had less functional coupling with delta/theta activity and less temporal processing. Finally, in humans this 2- to 6-Hz activity was correlated with executive function in matched controls but not in PD patients. Collectively, these findings suggest that cue-evoked low-frequency rhythms could be a clinically important biomarker of PD that is translatable to rodent models, facilitating mechanistic inquiry and the development of neurophysiological biomarkers for human disease.

Levodopa - therapeutic use

Frontal Lobe - physiopathology

Humans

Middle Aged

Rats, Long-Evans

Conditioning, Operant - physiology

Male

Delta Rhythm - physiology

Electroencephalography

Parkinson Disease - drug therapy

Oxidopamine

Parkinson Disease - physiopathology

Antiparkinson Agents - therapeutic use

Neuropsychological Tests

Animals

Neurons - physiology

Female

Time Perception - physiology

Dopamine - metabolism

Theta Rhythm - physiology

Details

Title: Subtitle: Medial frontal ∼4-Hz activity in humans and rodents is attenuated in PD patients and in rodents with cortical dopamine depletion
Creators: Krystal L Parker - Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, Iowa
Kuan-Hua Chen - Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, Iowa
Johnathan R Kingyon - Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, Iowa
James F Cavanagh - Department of Psychology, University of New Mexico, Albuquerque, New Mexico
Nandakumar S Narayanan - Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Aging Mind and Brain Initiative, Carver College of Medicine, University of Iowa, Iowa City, Iowa; and Nandakumar-narayanan@uiowa.edu
Resource Type: Journal article
Publication Details: Journal of neurophysiology, Vol.114(2), pp.1310-1320
DOI: 10.1152/jn.00412.2015
PMID: 26133799
PMCID: PMC4588517
NLM abbreviation: J Neurophysiol
ISSN: 0022-3077
eISSN: 1522-1598
Publisher: United States
Grant note: K08 NS078100 / NINDS NIH HHS R01 NS089470 / NINDS NIH HHS K01 MH106824 / NIMH NIH HHS
Language: English
Date published: 08/2015
Academic Unit: Neurology; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984003470602771

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