Medial prefrontal D1 dopamine neurons control food intake

Benjamin B Land; Nandakumar S Narayanan; Rong-Jian Liu; Carol A Gianessi; Catherine E Brayton; David M Grimaldi; Maysa Sarhan; Douglas J Guarnieri; Karl Deisseroth; George K Aghajanian; Ralph J DiLeone

doi:10.1038/nn.3625

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Medial prefrontal D1 dopamine neurons control food intake

Journal article

Peer reviewed

Medial prefrontal D1 dopamine neurons control food intake

Benjamin B Land, Nandakumar S Narayanan, Rong-Jian Liu, Carol A Gianessi, Catherine E Brayton, David M Grimaldi, Maysa Sarhan, Douglas J Guarnieri, Karl Deisseroth, George K Aghajanian, …

Nature neuroscience, Vol.17(2), pp.248-253

02/2014

DOI: 10.1038/nn.3625

PMCID: PMC3968853

PMID: 24441680

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https://www.ncbi.nlm.nih.gov/pmc/articles/3968853View

Open Access

Abstract

Although the prefrontal cortex influences motivated behavior, its role in food intake remains unclear. Here, we demonstrate a role for D1-type dopamine receptor-expressing neurons in the medial prefrontal cortex (mPFC) in the regulation of feeding. Food intake increases activity in D1 neurons of the mPFC in mice, and optogenetic photostimulation of D1 neurons increases feeding. Conversely, inhibition of D1 neurons decreases intake. Stimulation-based mapping of prefrontal D1 neuron projections implicates the medial basolateral amygdala (mBLA) as a downstream target of these afferents. mBLA neurons activated by prefrontal D1 stimulation are CaMKII positive and closely juxtaposed to prefrontal D1 axon terminals. Finally, photostimulating these axons in the mBLA is sufficient to increase feeding, recapitulating the effects of mPFC D1 stimulation. These data describe a new circuit for top-down control of food intake.

Biophysics

Membrane Potentials - genetics

Electric Stimulation

Channelrhodopsins

Male

Optogenetics

Neural Pathways - physiology

Eating - physiology

Receptors, Dopamine D1 - metabolism

Neural Inhibition - radiation effects

Photic Stimulation - adverse effects

Time Factors

Female

Neurons - metabolism

Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism

Membrane Potentials - drug effects

Neural Inhibition - genetics

Gene Expression Regulation - genetics

Mice, Inbred C57BL

Amygdala - metabolism

Mice, Transgenic

Functional Laterality

Prefrontal Cortex - cytology

Eating - genetics

Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics

Food Deprivation - physiology

Patch-Clamp Techniques

Animals

Analysis of Variance

Luminescent Proteins - genetics

Mice

In Vitro Techniques

Receptors, Dopamine D1 - genetics

Details

Title: Subtitle: Medial prefrontal D1 dopamine neurons control food intake
Creators: Benjamin B Land - Department of Psychiatry and Ribicoff Research Facilities, Yale University School of Medicine, New Haven, Connecticut, USA
Nandakumar S Narayanan - 1] Department of Psychiatry and Ribicoff Research Facilities, Yale University School of Medicine, New Haven, Connecticut, USA. Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
Rong-Jian Liu - Department of Psychiatry and Ribicoff Research Facilities, Yale University School of Medicine, New Haven, Connecticut, USA
Carol A Gianessi - Department of Psychiatry and Ribicoff Research Facilities, Yale University School of Medicine, New Haven, Connecticut, USA
Catherine E Brayton - Department of Psychiatry and Ribicoff Research Facilities, Yale University School of Medicine, New Haven, Connecticut, USA
David M Grimaldi - Department of Psychiatry and Ribicoff Research Facilities, Yale University School of Medicine, New Haven, Connecticut, USA
Maysa Sarhan - Department of Psychiatry and Ribicoff Research Facilities, Yale University School of Medicine, New Haven, Connecticut, USA
Douglas J Guarnieri - 1] Department of Psychiatry and Ribicoff Research Facilities, Yale University School of Medicine, New Haven, Connecticut, USA. Present address: Department of Biology, Colgate University, Hamilton, New York, USA
Karl Deisseroth - 1] Department of Bioengineering, Stanford University, Stanford, California, USA. Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA
George K Aghajanian - Department of Psychiatry and Ribicoff Research Facilities, Yale University School of Medicine, New Haven, Connecticut, USA
Ralph J DiLeone - Department of Psychiatry and Ribicoff Research Facilities, Yale University School of Medicine, New Haven, Connecticut, USA
Resource Type: Journal article
Publication Details: Nature neuroscience, Vol.17(2), pp.248-253
DOI: 10.1038/nn.3625
PMID: 24441680
PMCID: PMC3968853
NLM abbreviation: Nat Neurosci
ISSN: 1097-6256
eISSN: 1546-1726
Publisher: United States
Grant note: R01 DK098994 / NIDDK NIH HHS F32DK091172 / NIDDK NIH HHS R01DK098994 / NIDDK NIH HHS
Language: English
Date published: 02/2014
Academic Unit: Neurology; Iowa Neuroscience Institute
Record Identifier: 9984021000002771

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