Journal article
Medial prefrontal cortex acetylcholine injection-induced hypotension: the role of hindlimb vasodilation
Journal of the autonomic nervous system, Vol.79(1), pp.1-7
2000
DOI: 10.1016/S0165-1838(99)00091-0
PMID: 10683500
Abstract
The injection of acetylcholine (ACh) into the cingulate region of the medial prefrontal cortex (MPFC) causes a marked fall in arterial blood pressure which is not accompanied by changes in heart rate. The purpose of the present study was to investigate the hemodynamic basis for this stimulus-induced hypotension in Sprague–Dawley rats. The study was designed to determine whether a change in the vascular resistance of hindlimb, renal or mesenteric vascular beds contributes to the fall in arterial pressure in response to ACh injection into the cingulate cortex. Miniature pulsed-Doppler flow probes were used to measure changes in regional blood flow and vascular resistance. The results indicated that the hypotensive response was largely due to a consistent and marked vasodilation in the hindlimb vascular bed. On this basis, an additional experiment was then undertaken to determine the mechanisms that contribute to hindlimb vasodilation. The effect of interrupting the autonomic innervation of one leg on the hindlimb vasodilator response was tested. Unilateral transection of the lumbar sympathetic chain attenuated the cingulate ACh-induced vasodilation in the ipsilateral, but not in the contralateral hindlimb. These results suggest that the hypotensive response to cingulate cortex-ACh injection is caused by skeletal muscle vasodilation mediated by a sympathetic chain-related vasodilator system.
Details
- Title: Subtitle
- Medial prefrontal cortex acetylcholine injection-induced hypotension: the role of hindlimb vasodilation
- Creators
- Grasiele E Crippa - Department of Pharmacology, School of Medicine of Ribeirão Preto-USP, 14049-900, Ribeirão Preto, SP, BrazilStephen J Lewis - Department of Pharmacology and the Cardiovascular Center, University of Iowa, Iowa City, IA 52242, USAAlan Kim Johnson - Department of Pharmacology and the Cardiovascular Center, University of Iowa, Iowa City, IA 52242, USAFernando M.A Corrêa - Department of Pharmacology, School of Medicine of Ribeirão Preto-USP, 14049-900, Ribeirão Preto, SP, Brazil
- Resource Type
- Journal article
- Publication Details
- Journal of the autonomic nervous system, Vol.79(1), pp.1-7
- Publisher
- Elsevier B.V
- DOI
- 10.1016/S0165-1838(99)00091-0
- PMID
- 10683500
- ISSN
- 0165-1838
- eISSN
- 1872-7476
- Language
- English
- Date published
- 2000
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984213420302771
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