Medial prefrontal cortex and the temporal control of action

Qiang Zhang; Matthew A Weber; Nandakumar S Narayanan

doi:10.1016/bs.irn.2020.11.004

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Medial prefrontal cortex and the temporal control of action

Journal article

Peer reviewed

Medial prefrontal cortex and the temporal control of action

Qiang Zhang, Matthew A Weber and Nandakumar S Narayanan

International review of neurobiology, Vol.158, pp.421-441

2021

DOI: 10.1016/bs.irn.2020.11.004

PMID: 33785154

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https://www.ncbi.nlm.nih.gov/pmc/articles/8875599View

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Abstract

Across species, the medial prefrontal cortex guides actions in time. This process can be studied using behavioral paradigms such as simple reaction-time and interval-timing tasks. Temporal control of action can be influenced by prefrontal neurotransmitters such as dopamine and acetylcholine and is highly relevant to human diseases such as Parkinson's disease, schizophrenia, and attention-deficit hyperactivity disorder (ADHD). We review evidence that across species, medial prefrontal lesions impair the temporal control of action. We then consider neurophysiological correlates in humans, primates, and rodents that might encode temporal processing and relate to cognitive-control mechanisms. These data have informed brain-stimulation studies in rodents and humans that can compensate for timing deficits. This line of work illuminates basic mechanisms of temporal control of action in the medial prefrontal cortex, which underlies a range of high-level cognitive processing and could contribute to new biomarkers and therapies for human brain diseases.

Reaction time

Executive function

Dopamine

Interval timing

Prefrontal cortex

Details

Title: Subtitle: Medial prefrontal cortex and the temporal control of action
Creators: Qiang Zhang - Department of Neurology, University of Iowa, Iowa City, IA, United States
Matthew A Weber - Department of Neurology, University of Iowa, Iowa City, IA, United States
Nandakumar S Narayanan - Department of Neurology, University of Iowa, Iowa City, IA, United States. Electronic address: nandakumar-narayanan@uiowa.edu
Resource Type: Journal article
Publication Details: International review of neurobiology, Vol.158, pp.421-441
DOI: 10.1016/bs.irn.2020.11.004
PMID: 33785154
NLM abbreviation: Int Rev Neurobiol
ISSN: 0074-7742
eISSN: 2162-5514
Publisher: United States
Language: English
Date published: 2021
Academic Unit: Neurology; Iowa Neuroscience Institute
Record Identifier: 9984070576602771

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