Journal article
Mediastinal lymphatic drainage from pulmonary lobe based on CT observations of histoplasmosis: implications for minimal N2 disease of non-small-cell lung cancer
Radiation medicine, Vol.25(8), pp.393-401
10/2007
DOI: 10.1007/s11604-007-0156-0
PMID: 17952543
Abstract
The aim of this study was to assess mediastinal lymphatic drainage patterns from each pulmonary lobe using computed tomographic (CT) observations of calcified primary complex pulmonary histoplasmosis.
We assessed 400 CT studies of patients with primary complex histoplasmosis consisting of a single lobe pulmonary lesion and mediastinal nodal disease. We assessed the distribution of mediastinal nodal involvement depending on pulmonary lobes for the total number of involved nodes, the number with single-station involvement (which suggests the initial site of involvement), and the number with skip involvement which suggests direct drainage to the mediastinum.
The most commonly involved mediastinal nodal stations from the right upper lobe, left upper lobe, and left lower lobe were the right lower paratracheal node (97%, 74/76), the subaortic node (72%, 49/68), and the left pulmonary ligament node (61%, 66/108), respectively. These nodes were the most common site of skip involvement in each lobe. In the right lower lobe and middle lobe, the subcarinal node was most commonly involved: 62% (65/105) and 81% (35/43), respectively. By contrast, skip involvement was uncommon in the drainage to this node.
Our data show a predictable pattern of lobar lymphatic drainage to the mediastinum. This may have implications on the minimal N2 disease of non-small-cell lung cancer.
Details
- Title: Subtitle
- Mediastinal lymphatic drainage from pulmonary lobe based on CT observations of histoplasmosis: implications for minimal N2 disease of non-small-cell lung cancer
- Creators
- Koji Takahashi - Department of Radiology, Asahikawa Medical College and Hospital, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Japan. taka1019@asahikawa-med.ac.jpWilliam StanfordEdwin Van BeekBrad ThompsonBrian MullanYutaka Sato
- Resource Type
- Journal article
- Publication Details
- Radiation medicine, Vol.25(8), pp.393-401
- Publisher
- Japan
- DOI
- 10.1007/s11604-007-0156-0
- PMID
- 17952543
- ISSN
- 0288-2043
- eISSN
- 1862-5274
- Language
- English
- Date published
- 10/2007
- Academic Unit
- Radiology; Stead Family Department of Pediatrics; Internal Medicine
- Record Identifier
- 9984051524902771
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