Journal article
Mediator Complex Dependent Regulation of Cardiac Development and Disease
Genomics, proteomics & bioinformatics, Vol.11(3), pp.151-157
06/2013
DOI: 10.1016/j.gpb.2013.05.002
PMCID: PMC4357813
PMID: 23727265
Abstract
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality. The risk factors for CVD include environmental and genetic components. Human mutations in genes involved in most aspects of cardiovascular function have been identified, many of which are involved in transcriptional regulation. The Mediator complex serves as a pivotal transcriptional regulator that functions to integrate diverse cellular signals by multiple mechanisms including recruiting RNA polymerase II, chromatin modifying proteins and non-coding RNAs to promoters in a context dependent manner. This review discusses components of the Mediator complex and the contribution of the Mediator complex to normal and pathological cardiac development and function. Enhanced understanding of the role of this core transcriptional regulatory complex in the heart will help us gain further insights into CVD.
Details
- Title: Subtitle
- Mediator Complex Dependent Regulation of Cardiac Development and Disease
- Creators
- Chad E Grueter - Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Genomics, proteomics & bioinformatics, Vol.11(3), pp.151-157
- DOI
- 10.1016/j.gpb.2013.05.002
- PMID
- 23727265
- PMCID
- PMC4357813
- NLM abbreviation
- Genomics Proteomics Bioinformatics
- ISSN
- 1672-0229
- eISSN
- 2210-3244
- Publisher
- Elsevier Ltd
- Grant note
- DOI: 10.13039/100000968, name: American Heart Association, award: 13SDG14660064
- Language
- English
- Date published
- 06/2013
- Academic Unit
- Cardiovascular Medicine; Craniofacial Anomalies Research Center; Internal Medicine
- Record Identifier
- 9984094500002771
Metrics
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