Journal article
Mediator Web: a protein–protein interaction network database for the RNA polymerase II Mediator complex
The FEBS journal, Vol.291(17), pp.3938-3960
09/2024
DOI: 10.1111/febs.17225
PMID: 38975839
Abstract
The protein–protein interaction (PPI) network of the Mediator complex is very tightly regulated and depends on different developmental and environmental cues. Here, we present an interactive platform for comparative analysis of the Mediator subunits from humans, baker's yeast Saccharomyces cerevisiae , and model plant Arabidopsis thaliana in a user‐friendly web‐interface database called MediatorWeb. MediatorWeb provides an interface to visualize and analyze the PPI network of Mediator subunits. The database facilitates downloading the untargeted and unweighted network of Mediator complex, its submodules, and individual Mediator subunits to better visualize the importance of individual Mediator subunits or their submodules. Further, MediatorWeb offers network visualization of the Mediator complex and interacting proteins that are functionally annotated. This feature provides clues to understand functions of Mediator subunits in different processes. In an additional tab, MediatorWeb provides quick access to secondary and tertiary structures, as well as residue–level contact information for Mediator subunits in each of the three model organisms. Another useful feature of MediatorWeb is detection of interologs based on orthologous analyses, which can provide clues to understand the functions of Mediator complex in less explored kingdoms. Thus, MediatorWeb and its features can help the user to understand the role of Mediator complex and its subunits in the transcription regulation of gene expression.
Details
- Title: Subtitle
- Mediator Web: a protein–protein interaction network database for the RNA polymerase II Mediator complex
- Creators
- Sourobh Maji - University of DelhiMohd Waseem - Jawaharlal Nehru UniversityManish Kumar Sharma - National Institute of Plant Genome ResearchManinder Singh - National Institute of Plant Genome ResearchAnamika Singh - Plant Transcription Regulation International Centre for Genetic Engineering and Biotechnology New Delhi IndiaNidhi Dwivedi - National Institute of Plant Genome ResearchPallabi Thakur - National Institute of Plant Genome ResearchDavid G. Cooper - Butler UniversityNaveen C. Bisht - National Institute of Plant Genome ResearchJan S. Fassler - University of IowaNaidu Subbarao - Jawaharlal Nehru UniversityJitendra P. Khurana - University of DelhiNeel Sarovar Bhavesh - Transcription Regulation International Centre for Genetic Engineering and Biotechnology New Delhi IndiaJitendra Kumar Thakur - National Institute of Plant Genome Research
- Resource Type
- Journal article
- Publication Details
- The FEBS journal, Vol.291(17), pp.3938-3960
- DOI
- 10.1111/febs.17225
- PMID
- 38975839
- NLM abbreviation
- FEBS J
- ISSN
- 1742-464X
- eISSN
- 1742-4658
- Language
- English
- Electronic publication date
- 07/08/2024
- Date published
- 09/2024
- Academic Unit
- Biology
- Record Identifier
- 9984656628402771
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