Journal article
Mediators of the association between childhood trauma and pain sensitivity in adulthood: a Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network analysis
Pain (Amsterdam), Vol.164(9), pp.1995-2008
09/2023
DOI: 10.1097/j.pain.0000000000002895
PMCID: PMC10440258
PMID: 37144687
Abstract
Urologic chronic pelvic pain syndrome (UCPPS) is a complex, debilitating condition in which patients often report nonpelvic pain in addition to localized pelvic pain. Understanding differential predictors of pelvic pain only vs widespread pain may provide novel pathways for intervention. This study leveraged baseline data from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network's Symptom Pattern Study to investigate the impact of childhood sexual and nonsexual violent trauma on pelvic and nonpelvic pain sensitivity among adult patients with UCPPS, as well as potential mediators of this association. Study participants who met inclusion criteria for UCPPS completed questionnaires assessing childhood and recent trauma, affective distress, cognitive dysfunction, and generalized sensory sensitivity. Experimental pain sensitivity was also evaluated using standardized pressure pain applied to the pubic region and the arm. Bivariate analyses showed that childhood violent trauma was associated with more nonviolent childhood trauma, more recent trauma, poorer adult functioning, and greater pain sensitivity at the pubic region, but not pain sensitivity at the arm. Path analysis suggested that childhood violent trauma was indirectly associated with pain sensitivity at both sites and that this indirect association was primarily mediated by generalized sensory sensitivity. More experiences of recent trauma also contributed to these indirect effects. The findings suggest that, among participants with UCPPS, childhood violent trauma may be associated with heightened pain sensitivity to the extent that trauma history is associated with a subsequent increase in generalized sensory sensitivity.
Details
- Title: Subtitle
- Mediators of the association between childhood trauma and pain sensitivity in adulthood: a Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network analysis
- Creators
- Jennifer Pierce - University of MichiganSteven E Harte - University of MichiganNiloofar Afari - University of California San DiegoCatherine S Bradley - University of IowaJames W Griffith - Northwestern UniversityJayoung Kim - Cedars-Sinai Medical CenterSusan Lutgendorf - Department of Psychological and Brain Sciences, Department of Urology, and Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IA, United StatesBruce D Naliboff - University of California, Los AngelesLarissa V Rodriguez - Institute of Urology, University of Southern California, Beverly Hills, CA, United StatesBayley J Taple - Northwestern UniversityDavid Williams - University of MichiganRichard E Harris - University of MichiganAndrew Schrepf - University of MichiganMAPP Research Network
- Resource Type
- Journal article
- Publication Details
- Pain (Amsterdam), Vol.164(9), pp.1995-2008
- DOI
- 10.1097/j.pain.0000000000002895
- PMID
- 37144687
- PMCID
- PMC10440258
- NLM abbreviation
- Pain
- eISSN
- 1872-6623
- Language
- English
- Electronic publication date
- 05/05/2023
- Date published
- 09/2023
- Academic Unit
- Epidemiology; Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
- Record Identifier
- 9984400760102771
Metrics
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