Journal article
Medication therapy management and complex patients with disability: a randomized controlled trial
The Annals of pharmacotherapy, Vol.48(2), pp.158-167
02/2014
DOI: 10.1177/1060028013512472
PMID: 24259652
Abstract
Drug therapy problems, adverse drug events (ADEs), and symptom burden are high among adults with disabilities.
To compare the effects of a modified medication therapy management (MTM) program within a self-efficacy workshop versus the workshop alone or usual care on symptom burden among adults with activity limitations.
Three-group randomized controlled trial among adults (age 40 and older) with self-reported activity limitations in community practice.
8 weekly Living Well With a Disability (LWD) 2-hour workshop sessions with and without a collaborative medication management (CMM) module.
mean number of moderate to very severe symptoms from a list of 11 physical and mental symptoms. Process measures: changes in medication regimens and self-reported ADEs.
general linear mixed models (continuous outcomes) and generalized estimating equations (categorical outcomes).
Participants had high symptom burden, low physical health, and took many medications. There was a significant increase in ADE reporting in the LWD + CMM group relative to the other 2 groups (Study group × Time P = .014), and there were significantly more changes in medication regimens in the LWD + CMM group (P = .013 LWD only vs LWD + CMM). The oldest third of participants had significantly fewer mean symptoms but received more intense CMM. There was no difference between the LWD-only, LWD + CMM, and usual care groups in symptom burden over time.
Pharmacist MTM practices and MTM guidelines may need to be modified to affect symptom burden in a population with physical activity limitations.
Details
- Title: Subtitle
- Medication therapy management and complex patients with disability: a randomized controlled trial
- Creators
- Elizabeth A Chrischilles - University of Iowa, Iowa City, IA, USAWilliam DoucetteKaren FarrisScott LindgrenBrian GryzlakLinda RubensteinKelly YoulandRobert B Wallace
- Resource Type
- Journal article
- Publication Details
- The Annals of pharmacotherapy, Vol.48(2), pp.158-167
- DOI
- 10.1177/1060028013512472
- PMID
- 24259652
- NLM abbreviation
- Ann Pharmacother
- ISSN
- 1060-0280
- eISSN
- 1542-6270
- Publisher
- United States
- Grant note
- P30 ES005605 / NIEHS NIH HHS 5R01DD000107 / NCBDD CDC HHS
- Language
- English
- Date published
- 02/2014
- Academic Unit
- Pharmacy; Stead Family Department of Pediatrics; Epidemiology; Pharmacy Practice and Science; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9983995020202771
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