Medication use during pregnancy, with particular focus on prescription drugs: 1976-2008

Allen A Mitchell; Suzanne M Gilboa; Martha M Werler; Katherine E Kelley; Carol Louik; Sonia Hernández-Díaz; National Birth Defects Prevention Study

doi:10.1016/j.ajog.2011.02.029

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Medication use during pregnancy, with particular focus on prescription drugs: 1976-2008

Journal article

Peer reviewed

Medication use during pregnancy, with particular focus on prescription drugs: 1976-2008

Allen A Mitchell, Suzanne M Gilboa, Martha M Werler, Katherine E Kelley, Carol Louik, Sonia Hernández-Díaz and National Birth Defects Prevention Study

American journal of obstetrics and gynecology, Vol.205(1), pp.51.e1-51.e8

2011

DOI: 10.1016/j.ajog.2011.02.029

PMCID: PMC3793635

PMID: 21514558

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https://www.ncbi.nlm.nih.gov/pmc/articles/3793635View

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Abstract

The objective of the study was to provide information on overall medication use throughout pregnancy, with particular focus on the first trimester and specific prescription medications. The study design included the Slone Epidemiology Center Birth Defects Study, 1976-2008, and the National Birth Defects Prevention Study, 1997-2003, which together interviewed more than 30,000 women about their antenatal medication use. Over the last 3 decades, first-trimester use of prescription medication increased by more than 60%, and the use of 4 or more medications more than tripled. By 2008, approximately 50% of women reported taking at least 1 medication. Use of some specific medications markedly decreased or increased. Prescription medication use increased with maternal age and education, was highest for non-Hispanic whites, and varied by state. These data reflect the widespread and growing use of medications by pregnant women and reinforce the need to study their respective fetal risks and safety.

Epidemiology

Pregnancy

medications

over-the-counter medications

prescription medications

Details

Title: Subtitle: Medication use during pregnancy, with particular focus on prescription drugs: 1976-2008
Creators: Allen A Mitchell - Slone Epidemiology Center at Boston University, Boston, MA
Suzanne M Gilboa - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA
Martha M Werler - Slone Epidemiology Center at Boston University, Boston, MA
Katherine E Kelley - Slone Epidemiology Center at Boston University, Boston, MA
Carol Louik - Slone Epidemiology Center at Boston University, Boston, MA
Sonia Hernández-Díaz - Department of Epidemiology, Harvard School of Public Health, Boston, MA
National Birth Defects Prevention Study
Contributors: Paul A Romitti (Contributor) - University of Iowa, Epidemiology
Resource Type: Journal article
Publication Details: American journal of obstetrics and gynecology, Vol.205(1), pp.51.e1-51.e8
DOI: 10.1016/j.ajog.2011.02.029
PMID: 21514558
PMCID: PMC3793635
NLM abbreviation: Am J Obstet Gynecol
ISSN: 0002-9378
eISSN: 1097-6868
Publisher: Mosby, Inc
Grant note: R01 HD 046595 / Eunice Kennedy Shriver National Institute of Child Health and Human Development
Language: English
Date published: 2011
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9984214662502771

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