Journal article
Medications that relax the lower oesophageal sphincter and risk of oesophageal cancer: An analysis of two independent population-based databases
International journal of cancer, Vol.143(1), pp.22-31
07/01/2018
DOI: 10.1002/ijc.31293
PMID: 29396851
Abstract
Excessive lower oesophageal sphincter relaxation increases gastro-oesophageal acid reflux, an oesophageal adenocarcinoma risk factor. Medications that relax this sphincter (benzodiazepines, calcium channel blockers, nitrates, β2 agonists and xanthines) could promote cancer. These medications were investigated in two independent datasets. In the Scottish Primary Care Clinical Informatics Unit (PCCIU) database, a nested case-control study of oesophageal cancer was performed using GP prescription records. Conditional logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CIs) for medication use and oesophageal cancer. In UK Biobank, a cohort study was conducted using self-reported medication use. Cox regression was used to calculate hazard ratios (HRs) and 95% CIs for medication use and oesophageal cancer, and by tumour subtype. Overall, 1,979 oesophageal cancer patients were matched to 9,543 controls in PCCIU, and 355 of 475,768 participants developed oesophageal cancer in UK Biobank. None of the medications investigated were significantly associated with oesophageal cancer risk apart from β2 agonists, which were associated with increased oesophageal cancer risk in PCCIU (adjusted OR 1.38, 95% CI 1.12, 1.70) but not in UK Biobank (adjusted HR 1.21, 95% CI 0.70, 2.08). Medications that relax the lower oesophageal sphincter were not associated with oesophageal cancer, apart from β2 agonists. This increased cancer risk in β2 agonist users merits further investigation.
Details
- Title: Subtitle
- Medications that relax the lower oesophageal sphincter and risk of oesophageal cancer: An analysis of two independent population-based databases
- Creators
- Andrew D Spence - Cancer Epidemiology and Health Services Research Group, Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, United KingdomJohn Busby - Cancer Epidemiology and Health Services Research Group, Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, United KingdomPeter Murchie - Academic Primary Care, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, United KingdomAndrew T Kunzmann - Cancer Epidemiology and Health Services Research Group, Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, United KingdomÚna C McMenamin - Cancer Epidemiology and Health Services Research Group, Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, United KingdomHelen G Coleman - Cancer Epidemiology and Health Services Research Group, Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, United KingdomBrian T Johnston - Belfast Health and Social Care Trust, Belfast, Northern Ireland, United KingdomMichael A O'Rorke - Cancer Epidemiology and Health Services Research Group, Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, United KingdomLiam J Murray - Cancer Epidemiology and Health Services Research Group, Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, United KingdomLisa Iversen - Academic Primary Care, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, United KingdomAmanda J Lee - University of AberdeenChris R Cardwell - Cancer Epidemiology and Health Services Research Group, Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom
- Resource Type
- Journal article
- Publication Details
- International journal of cancer, Vol.143(1), pp.22-31
- Publisher
- United States
- DOI
- 10.1002/ijc.31293
- PMID
- 29396851
- ISSN
- 0020-7136
- eISSN
- 1097-0215
- Grant note
- MC_QA137853 / Medical Research Council
- Language
- English
- Date published
- 07/01/2018
- Academic Unit
- Epidemiology; Pathology
- Record Identifier
- 9983995168202771
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