Medullary respiratory neurons in the guinea pig: localization and firing patterns

George B Richerson; Peter A Getting

doi:10.1016/0006-8993(92)90980-N

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Medullary respiratory neurons in the guinea pig: localization and firing patterns

Journal article

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Peer reviewed

Medullary respiratory neurons in the guinea pig: localization and firing patterns

George B Richerson and Peter A Getting

Brain research, Vol.591(1), pp.79-87

1992

DOI: 10.1016/0006-8993(92)90980-N

PMID: 1446235

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Abstract

The location and firing patterns of medullary respiratory neurons have been described in a small number of species. The cat has been the most widely studied species, but some potentially important differences have recently been noted in others. A more complete survey of species is required to determine the significance of these differences. We describe the location and firing patterns of respiratory neurons in the medulla of anesthetized, paralyzed and mechanically ventilated adult guinea pigs. Extracellular single-unit recordings were made from the medulla, their phase relationship with phrenic nerve activity used to define them as respiratory and their location marked with fast green. Respiratory units were concentrated ventrolateral to the nucleus tractus solitarius (NTS) and within and surrounding the nucleus ambiguus (NA), corresponding to the dorsal respiratory group (DRG) and ventral respiratory group (VRG) of the cat, respectively. Most DRG respiratory units were inspiratory, while the VRG contained equal numbers of inspiratory and expiratory units. The DRG and VRG both contained early, late and constant-frequency inspiratory and expiratory units. In general, these findings are similar to those in other mammalian species examined, consistent with these basic aspects of the respiratory network being highly conserved.

Inspiration

Dorsal respiratory group

Nucleus tractus solitarius

Nucleus ambiguus

Expiration

Electrophysiology

Ventral respiratory group

Details

Title: Subtitle: Medullary respiratory neurons in the guinea pig: localization and firing patterns
Creators: George B Richerson - Department of Physiology and Biophysics, University of Iowa, College of Medicine, Iowa City, IA 52242 USA
Peter A Getting - Department of Physiology and Biophysics, University of Iowa, College of Medicine, Iowa City, IA 52242 USA
Resource Type: Journal article
Publication Details: Brain research, Vol.591(1), pp.79-87
DOI: 10.1016/0006-8993(92)90980-N
PMID: 1446235
NLM abbreviation: Brain Res
ISSN: 0006-8993
eISSN: 1872-6240
Publisher: Elsevier B.V
Language: English
Date published: 1992
Academic Unit: Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Neurosurgery
Record Identifier: 9984020876802771

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