Journal article
Medullary serotonin neurons and central CO2 chemoreception
Respiratory physiology & neurobiology, Vol.168(1-2), pp.49-58
08/31/2009
DOI: 10.1016/j.resp.2009.04.014
PMCID: PMC2787387
PMID: 19394450
Abstract
Serotonergic (5-HT) neurons are putative central respiratory chemoreceptors, aiding in the brain’s ability to detect arterial changes in P
CO
2
and implement appropriate ventilatory responses to maintain blood homeostasis. These neurons are in close proximity to large medullary arteries and are intrinsically chemosensitive
in vitro
, characteristics expected for chemoreceptors. 5-HT neurons of the medullary raphé are stimulated by hypercapnia
in vivo
, and their disruption results in a blunted hypercapnic ventilatory response. More recently, data collected from transgenic and knock-out mice have provided further insight into the role of 5-HT in chemosensitivity. This review summarizes current evidence in support of the hypothesis that 5-HT neurons are central chemoreceptors, and addresses arguments made against this role. We also briefly explore the relationship between the medullary raphé and another chemoreceptive site, the retrotrapezoid nucleus, and discuss how they may interact during hypercapnia to produce a robust ventilatory response.
Details
- Title: Subtitle
- Medullary serotonin neurons and central CO2 chemoreception
- Creators
- Andrea E Corcoran - Dept of Biology and Wildlife, University of Alaska Fairbanks, Fairbanks, AK 99775Matthew R Hodges - Department of Neurology, Yale University, New Haven, CT 06520Yuanming Wu - Department of Neurology, Yale University, New Haven, CT 06520Wengang Wang - Department of Neurology, Yale University, New Haven, CT 06520Christie J Wylie - Dept. of Neurosciences, Case Western Reserve University, Cleveland, OH 44106Evan S Deneris - Dept. of Neurosciences, Case Western Reserve University, Cleveland, OH 44106George B Richerson - Department of Neurology, Yale University, New Haven, CT 06520
- Resource Type
- Journal article
- Publication Details
- Respiratory physiology & neurobiology, Vol.168(1-2), pp.49-58
- DOI
- 10.1016/j.resp.2009.04.014
- PMID
- 19394450
- PMCID
- PMC2787387
- NLM abbreviation
- Respir Physiol Neurobiol
- ISSN
- 1569-9048
- eISSN
- 1878-1519
- Language
- English
- Date published
- 08/31/2009
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984020759802771
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