Medullary serotonin neurons and their roles in central respiratory chemoreception

Matthew R Hodges; George B Richerson

doi:10.1016/j.resp.2010.03.006

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Medullary serotonin neurons and their roles in central respiratory chemoreception

Journal article

Peer reviewed

Medullary serotonin neurons and their roles in central respiratory chemoreception

Matthew R Hodges and George B Richerson

Respiratory physiology & neurobiology, Vol.173(3), pp.256-263

2010

DOI: 10.1016/j.resp.2010.03.006

PMCID: PMC4554718

PMID: 20226279

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Abstract

Much progress has been made in our understanding of central chemoreception since the seminal experiments of Fencl, Loeschcke, Mitchell and others, including identification of new brainstem regions and specific neuron types that may serve as central “sensors” of CO 2/pH. In this review, we discuss key attributes, or minimal requirements a neuron/cell must possess to be defined as a central respiratory chemoreceptor, and summarize how well each of the various candidates fulfill these minimal criteria—especially the presence of intrinsic chemosensitivity. We then discuss some of the in vitro and in vivo evidence in support of the conclusion that medullary serotonin (5-HT) neurons are central chemoreceptors. We also provide an additional hypothesis that chemosensitive medullary 5-HT neurons are poised to integrate multiple synaptic inputs from various other sources thought to influence ventilation. Finally, we discuss open questions and future studies that may aid in continuing our advances in understanding central chemoreception.

Medullary serotonin

pH/CO 2

Respiratory chemoreceptor

Details

Title: Subtitle: Medullary serotonin neurons and their roles in central respiratory chemoreception
Creators: Matthew R Hodges - Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, United States
George B Richerson - Departments of Neurology, and Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06520, United States
Resource Type: Journal article
Publication Details: Respiratory physiology & neurobiology, Vol.173(3), pp.256-263
DOI: 10.1016/j.resp.2010.03.006
PMID: 20226279
PMCID: PMC4554718
NLM abbreviation: Respir Physiol Neurobiol
ISSN: 1569-9048
eISSN: 1878-1519
Publisher: Elsevier B.V
Language: English
Date published: 2010
Academic Unit: Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Neurosurgery
Record Identifier: 9984020796202771

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