Journal article
Meiosis gene inventory of four ciliates reveals the prevalence of a synaptonemal complex-independent crossover pathway
Molecular biology and evolution, Vol.31(3), pp.660-672
03/2014
DOI: 10.1093/molbev/mst258
PMID: 24336924
Abstract
To establish which meiosis genes are present in ciliates, and to look for clues as to which recombination pathways may be treaded by them, four genomes were inventoried for 11 meiosis-specific and 40 meiosis-related genes. We found that the set of meiosis genes shared by Tetrahymena thermophila, Paramecium tetraurelia, Ichthyophthirius multifiliis, and Oxytricha trifallax is consistent with the prevalence of a Mus81-dependent class II crossover pathway that is considered secondary in most model eukaryotes. There is little evidence for a canonical class I crossover pathway that requires the formation of a synaptonemal complex (SC). This gene inventory suggests that meiotic processes in ciliates largely depend on mitotic repair proteins for executing meiotic recombination. We propose that class I crossovers and SCs were reduced sometime during the evolution of ciliates. Consistent with this reduction, we provide microscopic evidence for the presence only of degenerate SCs in Stylonychia mytilus. In addition, lower nonsynonymous to synonymous mutation rates of some of the meiosis genes suggest that, in contrast to most other nuclear genes analyzed so far, meiosis genes in ciliates are largely evolving at a slower rate than those genes in fungi and animals.
Details
- Title: Subtitle
- Meiosis gene inventory of four ciliates reveals the prevalence of a synaptonemal complex-independent crossover pathway
- Creators
- Jingyun Chi - Department of Ecology, University of Kaiserslautern, Kaiserslautern, GermanyFrédéric MahéJosef LoidlJohn LogsdonMicah Dunthorn
- Resource Type
- Journal article
- Publication Details
- Molecular biology and evolution, Vol.31(3), pp.660-672
- DOI
- 10.1093/molbev/mst258
- PMID
- 24336924
- ISSN
- 0737-4038
- eISSN
- 1537-1719
- Language
- English
- Date published
- 03/2014
- Academic Unit
- Biology
- Record Identifier
- 9984217415002771
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