Journal article
Melatonin and pinoline prevent aluminium-induced lipid peroxidation in rat synaptosomes
Journal of trace elements in medicine and biology, Vol.17(1), pp.39-44
2003
DOI: 10.1016/S0946-672X(03)80044-5
PMID: 12755500
Abstract
The serum concentrations of aluminum, a metal potentially involved in the pathogenesis of Alzheimer's disease, increase with age. Also, intense and prolonged exposure to aluminum may result in dementia. Melatonin and pinoline are two well known antioxidants that efficiently reduce lipid peroxidation due to oxidative stress. Herein, we investigated the effects of melatonin and pinoline in preventing aluminum promotion of lipid peroxidation when the metal was combined with FeCl
3 and ascorbic acid in rat synaptosomal membranes. Lipid peroxidation was estimated by quantifying malondialdehyde (MDA) and 4-hydroxyalkenal (4-HDA) concentrations in the membrane suspension. Under the experimental conditions used herein, the addition of aluminum (0.0001 to 1 mmol/L) enhanced MDA + 4-HDA formation in the synaptosomes. Melatonin and pinoline reduced, in a concentration-dependent manner, lipid peroxidation due to aluminum, FeCl
3 and ascorbic acid in the synaptosomal membranes. These results suggest that the indoleamine melatonin and the β-carboline pinoline may potentially act as neuroprotectant agents in the therapy of those diseases with elevated aluminum concentrations in the tissues.
Details
- Title: Subtitle
- Melatonin and pinoline prevent aluminium-induced lipid peroxidation in rat synaptosomes
- Creators
- Sergio Millán-Plano - Department of Pharmacology and Physiology, University of Zaragoza, SpainJoaquin J García - Department of Pharmacology and Physiology, University of Zaragoza, SpainEnrique Martínez-Ballarín - Department of Pharmacology and Physiology, University of Zaragoza, SpainRussel J Reiter - Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, USASantiago Ortega-Gutiérrez - Department of Pharmacology and Physiology, University of Zaragoza, SpainRosa Maria Lázaro - Department of Pharmacology and Physiology, University of Zaragoza, SpainJesos Fernando Escanero - Department of Pharmacology and Physiology, University of Zaragoza, Spain
- Resource Type
- Journal article
- Publication Details
- Journal of trace elements in medicine and biology, Vol.17(1), pp.39-44
- DOI
- 10.1016/S0946-672X(03)80044-5
- PMID
- 12755500
- NLM abbreviation
- J Trace Elem Med Biol
- ISSN
- 0946-672X
- eISSN
- 1878-3252
- Publisher
- Elsevier GmbH
- Language
- English
- Date published
- 2003
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984020747502771
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