Journal article
Melatonin improves deferoxamine antioxidant activity in protecting against lipid peroxidation caused by hydrogen peroxide in rat brain homogenates
Neuroscience letters, Vol.323(1), pp.55-59
2002
DOI: 10.1016/S0304-3940(01)02530-7
PMID: 11911989
Abstract
Deferoxamine (DF) is an antioxidant molecule because of its ability to chelate iron. This study compared the ability of DF alone or in combination with melatonin, 5-methoxytryptophol or pinoline in preventing lipid peroxidation due to hydrogen peroxide (H
2O
2) in rat brain homogenates. Malondialdehyde (MDA) and 4-hydroxyalkenals (4-HDA) in the homogenates were measured as indices of lipid peroxidation. Incubation of homogenates with DF reduced, in a dose-dependent manner, MDA+4-HDA formation due to H
2O
2. When melatonin, 5-methoxytryptophol or pinoline were added to the incubation medium, the efficacy of DF in preventing lipid peroxidation was enhanced. These cooperative effects between DF, melatonin, and related pineal products may be important in protecting tissues from the oxidative stress due to iron overload.
Details
- Title: Subtitle
- Melatonin improves deferoxamine antioxidant activity in protecting against lipid peroxidation caused by hydrogen peroxide in rat brain homogenates
- Creators
- S Ortega-Gutiérrez - Department of Pharmacology and Physiology, University of Zaragoza, Zaragoza, SpainJ.J Garcı́a - Department of Pharmacology and Physiology, University of Zaragoza, Zaragoza, SpainE Martı́nez-Balları́n - Department of Pharmacology and Physiology, University of Zaragoza, Zaragoza, SpainR.J Reiter - Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USAS Millán-Plano - Department of Pharmacology and Physiology, University of Zaragoza, Zaragoza, SpainM Robinson - Department of Pharmacology and Physiology, University of Zaragoza, Zaragoza, SpainD Acuña-Castroviejo - Department of Physiology, University of Granada, Granada, Spain
- Resource Type
- Journal article
- Publication Details
- Neuroscience letters, Vol.323(1), pp.55-59
- DOI
- 10.1016/S0304-3940(01)02530-7
- PMID
- 11911989
- NLM abbreviation
- Neurosci Lett
- ISSN
- 0304-3940
- eISSN
- 1872-7972
- Publisher
- Elsevier Ireland Ltd
- Language
- English
- Date published
- 2002
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984020886302771
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