Journal article
Memory B cells from a subset of treatment-naïve relapsing-remitting multiple sclerosis patients elicit CD4(+) T-cell proliferation and IFN-γ production in response to myelin basic protein and myelin oligodendrocyte glycoprotein
European journal of immunology, Vol.40(10), pp.2942-2956
10/2010
DOI: 10.1002/eji.201040516
PMCID: PMC3072802
PMID: 20812237
Abstract
Recent evidence suggests that B- and T-cell interactions may be paramount in relapsing-remitting MS (RRMS) disease pathogenesis. We hypothesized that memory B-cell pools from RRMS patients may specifically harbor a subset of potent neuro-APC that support neuro-Ag reactive T-cell proliferation and cytokine secretion. To test this hypothesis, we compared CD80 and HLA-DR expression, IL-10 and lymphotoxin-α secretion, neuro-Ag binding capacity, and neuro-Ag presentation by memory B cells from RRMS patients to naïve B cells from RRMS patients and to memory and naïve B cells from healthy donors (HD). We identified memory B cells from some RRMS patients that elicited CD4(+) T-cell proliferation and IFN-γ secretion in response to myelin basic protein and myelin oligodendrocyte glycoprotein. Notwithstanding the fact that the phenotypic parameters that promote efficient Ag presentation were observed to be similar between RRMS and HD memory B cells, a corresponding capability to elicit CD4(+) T-cell proliferation in response to myelin basic protein and myelin oligodendrocyte glycoprotein was not observed in HD memory B cells. Our results demonstrate for the first time that the memory B-cell pool in RRMS harbors neuro-Ag specific B cells that can activate T cells.
Details
- Title: Subtitle
- Memory B cells from a subset of treatment-naïve relapsing-remitting multiple sclerosis patients elicit CD4(+) T-cell proliferation and IFN-γ production in response to myelin basic protein and myelin oligodendrocyte glycoprotein
- Creators
- Christopher T Harp - Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USASara IrelandLaurie S DavisGina RemingtonBonnie CassidyPetra D CravensOlaf StuveAmy E Lovett-RackeTodd N EagarBenjamin M GreenbergMichael K RackeLindsay G CowellNitin J KarandikarElliot M FrohmanNancy L Monson
- Resource Type
- Journal article
- Publication Details
- European journal of immunology, Vol.40(10), pp.2942-2956
- Publisher
- Germany
- DOI
- 10.1002/eji.201040516
- PMID
- 20812237
- PMCID
- PMC3072802
- ISSN
- 0014-2980
- eISSN
- 1521-4141
- Grant note
- T32 AI005284-28 / NIAID NIH HHS K24 AI079272 / NIAID NIH HHS T32 AI005284 / NIAID NIH HHS
- Language
- English
- Date published
- 10/2010
- Academic Unit
- Pathology
- Record Identifier
- 9984047674202771
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