Journal article
Memory CD8+ T cell-mediated protection against liver-stage malaria
Immunological reviews, Vol.316(1), pp.84-103
07/2023
DOI: 10.1111/imr.13202
PMCID: PMC10524177
PMID: 37014087
Appears in UI Libraries Support Open Access
Abstract
Nearly half of the world's population is at risk of malaria, a disease caused by the protozoan parasite Plasmodium, which is estimated to cause more than 240,000,000 infections and kill more than 600,000 people annually. The emergence of Plasmodia resistant to chemoprophylactic treatment highlights the urgency to develop more effective vaccines. In this regard, whole sporozoite vaccination approaches in murine models and human challenge studies have provided substantial insight into the immune correlates of protection from malaria. From these studies, CD8+ T cells have come to the forefront, being identified as critical for vaccine-mediated liver-stage immunity that can prevent the establishment of the symptomatic blood stages and subsequent transmission of infection. However, the unique biological characteristics required for CD8+ T cell protection from liver-stage malaria dictate that more work must be done to design effective vaccines. In this review, we will highlight a subset of studies that reveal basic aspects of memory CD8+ T cell-mediated protection from liver-stage malaria infection.
Details
- Title: Subtitle
- Memory CD8+ T cell-mediated protection against liver-stage malaria
- Creators
- Mariah Hassert - Department of Pathology, University of Iowa-Carver College of Medicine, Iowa City, Iowa, USASahaana Arumugam - Interdisciplinary Graduate Program in Immunology, University of Iowa-Carver College of Medicine, Iowa City, Iowa, USAJohn T Harty - Interdisciplinary Graduate Program in Immunology, University of Iowa-Carver College of Medicine, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Immunological reviews, Vol.316(1), pp.84-103
- DOI
- 10.1111/imr.13202
- PMID
- 37014087
- PMCID
- PMC10524177
- NLM abbreviation
- Immunol Rev
- eISSN
- 1600-065X
- Publisher
- Wiley
- Grant note
- F32AI174382 / National Institute of Allergy and Infectious Diseases RO1AI167847 / National Institute of Allergy and Infectious Diseases RO1AI085515 / National Institute of Allergy and Infectious Diseases RO1AI095178 / National Institute of Allergy and Infectious Diseases T32 AI007260 / NIAID NIH HHS RO1AI100527 / National Institute of Allergy and Infectious Diseases
- Language
- English
- Electronic publication date
- 04/04/2023
- Date published
- 07/2023
- Academic Unit
- Pathology
- Record Identifier
- 9984385048402771
Metrics
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