Journal article
Memory Enhancement and Deep-Brain Stimulation of the Entorhinal Area
The New England journal of medicine, Vol.366(20), pp.1945-1946
05/17/2012
DOI: 10.1056/NEJMc1203204
PMID: 22591306
Abstract
To the Editor:
The study by Suthana and coworkers (Feb. 9 issue)
1
involved patients with pharmacoresistant epilepsy who underwent implantation of intracranial depth electrodes before possible surgical resection. The authors found that stimulation of the entorhinal cortex, but not of the hippocampus proper, during the learning phase of a spatial-navigation task resulted in more efficient performance. This finding may serve as a starting point for future neuromodulatory interventions aimed at treating disorders with medial temporal-lobe dysfunction and associated cognitive dysfunction. In the context of identification of therapeutic targets, a more precise description of electrode localization, especially along the anterior-posterior axis, . . .
Details
- Title: Subtitle
- Memory Enhancement and Deep-Brain Stimulation of the Entorhinal Area
- Creators
- Andres H Neuhaus - Charité University Medicine, Berlin, GermanyMalek Bajbouj - Charité University Medicine, Berlin, GermanyKatsuhiro Kobayashi - Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, JapanHarumi Yoshinaga - Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, JapanYoko Ohtsuka - Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, JapanBrian J Dlouhy - University of Iowa Hospitals and Clinics, Iowa City, IARajesh C Rao - Washington University School of Medicine, St. Louis, MONanthia Suthana - University of California, Los Angeles, Los Angeles, CAItzhak Fried - University of California, Los Angeles, Los Angeles, CA
- Resource Type
- Journal article
- Publication Details
- The New England journal of medicine, Vol.366(20), pp.1945-1946
- Publisher
- Massachusetts Medical Society
- DOI
- 10.1056/NEJMc1203204
- PMID
- 22591306
- ISSN
- 0028-4793
- eISSN
- 1533-4406
- Language
- English
- Date published
- 05/17/2012
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984070423402771
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