Memory consolidation within the central amygdala is not necessary for modulation of cerebellar learning

Adam B Steinmetz; Ka H Ng; John H Freeman

doi:10.1101/lm.045310.117

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Memory consolidation within the central amygdala is not necessary for modulation of cerebellar learning

Journal article

Open access

Peer reviewed

Memory consolidation within the central amygdala is not necessary for modulation of cerebellar learning

Adam B Steinmetz, Ka H Ng and John H Freeman

Learning & memory (Cold Spring Harbor, N.Y.), Vol.24(6), pp.225-230

06/2017

DOI: 10.1101/lm.045310.117

PMCID: PMC5435882

PMID: 28507031

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Abstract

Amygdala lesions impair, but do not prevent, acquisition of cerebellum-dependent eyeblink conditioning suggesting that the amygdala modulates cerebellar learning. Two-factor theories of eyeblink conditioning posit that a fast-developing memory within the amygdala facilitates slower-developing memory within the cerebellum. The current study tested this hypothesis by impairing memory consolidation within the amygdala with inhibition of protein synthesis, transcription, and NMDA receptors in rats. Rats given infusions of anisomycin or DRB into the central amygdala (CeA) immediately after each eyeblink conditioning session were severely impaired in contextual and cued fear conditioning, but were completely unimpaired in eyeblink conditioning. Rats given the NMDA antagonist ifenprodil into the CeA before each eyeblink conditioning session also showed impaired fear conditioning, but no deficit in eyeblink conditioning. The results indicate that memory formation within the CeA is not necessary for its modulation of cerebellar learning mechanisms. The CeA may modulate cerebellar learning and retention through an attentional mechanism that develops within the training sessions.

Central Amygdaloid Nucleus - drug effects

Conditioning, Classical - drug effects

Memory Consolidation - drug effects

Rats, Long-Evans

Cerebellum - drug effects

Rats

Male

Excitatory Amino Acid Antagonists - pharmacology

Dichlororibofuranosylbenzimidazole - pharmacology

Cerebellum - physiology

Conditioning, Classical - physiology

Central Amygdaloid Nucleus - physiology

Memory Consolidation - physiology

Conditioning, Eyelid - physiology

Animals

Piperidines - pharmacology

Anisomycin - pharmacology

Electromyography

Protein Synthesis Inhibitors - pharmacology

Conditioning, Eyelid - drug effects

Details

Title: Subtitle: Memory consolidation within the central amygdala is not necessary for modulation of cerebellar learning
Creators: Adam B Steinmetz - Center for Neural Science, New York University, New York, New York 10003, USA
Ka H Ng - Department of Psychological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
John H Freeman - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa 52242, USA
Resource Type: Journal article
Publication Details: Learning & memory (Cold Spring Harbor, N.Y.), Vol.24(6), pp.225-230
DOI: 10.1101/lm.045310.117
PMID: 28507031
PMCID: PMC5435882
NLM abbreviation: Learn Mem
ISSN: 1072-0502
eISSN: 1549-5485
Publisher: United States
Grant note: R01 NS088567 / NINDS NIH HHS
Language: English
Date published: 06/2017
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984065755702771

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