Journal article
Memory for items and relationships among items embedded in realistic scenes: disproportionate relational memory impairments in amnesia
Neuropsychology, Vol.29(1), pp.126-138
01/2015
DOI: 10.1037/neu0000119
PMCID: PMC4286539
PMID: 25068665
Abstract
The objective of this study was to examine the dependence of item memory and relational memory on medial temporal lobe (MTL) structures. Patients with amnesia, who either had extensive MTL damage or damage that was relatively restricted to the hippocampus, were tested, as was a matched comparison group. Disproportionate relational memory impairments were predicted for both patient groups, and those with extensive MTL damage were also expected to have impaired item memory.
Participants studied scenes, and were tested with interleaved 2-alternative forced-choice probe trials. Probe trials were either presented immediately after the corresponding study trial (Lag 1), 5 trials later (Lag 5), or 9 trials later (Lag 9) and consisted of the studied scene along with a manipulated version of that scene in which 1 item was replaced with a different exemplar (item memory test) or was moved to a new location (relational memory test). Participants were to identify the exact match of the studied scene.
As predicted, patients were disproportionately impaired on the test of relational memory. Item memory performance was marginally poorer among patients with extensive MTL damage, but both groups were impaired relative to matched comparison participants. Impaired performance was evident at all lags, including the shortest possible lag (Lag 1).
The results are consistent with the proposed role of the hippocampus in relational memory binding and representation, even at short delays, and suggest that the hippocampus may also contribute to successful item memory when items are embedded in complex scenes.
Details
- Title: Subtitle
- Memory for items and relationships among items embedded in realistic scenes: disproportionate relational memory impairments in amnesia
- Creators
- Deborah E Hannula - Department of Psychology, University of Wisconsin, MilwaukeeDaniel Tranel - Department of Psychology, University of IowaJohn S Allen - Dornsife Cognitive Neuroscience Imaging Center and Brain and Creativity Institute, University of Southern CaliforniaBrenda A Kirchhoff - Department of Psychology, Saint Louis UniversityAllison E Nickel - Department of Psychology, University of Wisconsin, MilwaukeeNeal J Cohen - Department of Psychology, University of Illinois, Urbana-Champaign
- Resource Type
- Journal article
- Publication Details
- Neuropsychology, Vol.29(1), pp.126-138
- DOI
- 10.1037/neu0000119
- PMID
- 25068665
- PMCID
- PMC4286539
- NLM abbreviation
- Neuropsychology
- ISSN
- 0894-4105
- eISSN
- 1931-1559
- Publisher
- American Psychological Association (APA); United States
- Grant note
- R01 DA022549 / NIDA NIH HHS P01 NS019632 / NINDS NIH HHS R01 MH062500 / NIMH NIH HHS P01 NS19632 / NINDS NIH HHS
- Language
- English
- Date published
- 01/2015
- Academic Unit
- Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984002357402771
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