Memory impairment in cognitively impaired aged rats associated with decreased hippocampal CREB phosphorylation: reversal by procyanidins extracted from the lotus seedpod

Jiqu Xu; Shuang Rong; Bijun Xie; Zhida Sun; Qianchun Deng; Hailei Wu; Wei Bao; Di Wang; Ping Yao; Fenghong Huang; Liegang Liu

doi:10.1093/gerona/glq094

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Memory impairment in cognitively impaired aged rats associated with decreased hippocampal CREB phosphorylation: reversal by procyanidins extracted from the lotus seedpod

Journal article

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Memory impairment in cognitively impaired aged rats associated with decreased hippocampal CREB phosphorylation: reversal by procyanidins extracted from the lotus seedpod

Jiqu Xu, Shuang Rong, Bijun Xie, Zhida Sun, Qianchun Deng, Hailei Wu, Wei Bao, Di Wang, Ping Yao, Fenghong Huang, …

The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.65(9), pp.933-940

09/2010

DOI: 10.1093/gerona/glq094

PMID: 20530246

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Abstract

The major purpose of this study was to determine the effects of procyanidins extracted from the lotus seedpod on cAMP-response element-binding protein phosphorylation in hippocampus and cerebral cortex in cognitively impaired aged rats. Based on Morris water maze, aged unimpaired and aged impaired rats were chosen from aged rats. Comparing with young and aged unimpaired animals, aged impaired rats exhibited significant reduction in hippocampal but not cortical cAMP-response element-binding phosphorylation states as well as brain-derived neurotrophic factor messenger RNA and protein expressions, which were accompanied by decreased phosphorylation states of hippocampal extracellular signal-related kinase (42/44) and calcium calmodulin kinase IV. Lotus seedpod supplementation (50 and 100 mg/kg body weight intragastric administration) for 7 weeks significantly reversed all these declines happened in hippocampus except calcium calmodulin kinase IV phosphorylation levels. These results suggested that lotus seedpod might enhance cAMP-response element-binding-dependent transcription through the activation of extracellular signal-related kinase signalling pathway, which might contribute to its ameliorative effects on cognitive deficits in aged impaired animals.

Phosphorylation

Aging

Protein Kinase C-alpha - metabolism

Calcium-Calmodulin-Dependent Protein Kinase Type 4 - metabolism

Plant Extracts - pharmacology

Rats

Extracellular Signal-Regulated MAP Kinases - metabolism

Rats, Sprague-Dawley

Cerebral Cortex - metabolism

CREB-Binding Protein - metabolism

Hippocampus - metabolism

Cognition Disorders - complications

Animals

Maze Learning

Memory Disorders - drug therapy

Proanthocyanidins - pharmacology

Female

Brain-Derived Neurotrophic Factor - metabolism

Loteae

RNA, Messenger

Details

Title: Subtitle: Memory impairment in cognitively impaired aged rats associated with decreased hippocampal CREB phosphorylation: reversal by procyanidins extracted from the lotus seedpod
Creators: Jiqu Xu - Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China
Shuang Rong
Bijun Xie
Zhida Sun - Huazhong Agricultural University
Qianchun Deng
Hailei Wu
Wei Bao
Di Wang
Ping Yao
Fenghong Huang
Liegang Liu
Resource Type: Journal article
Publication Details: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.65(9), pp.933-940
Publisher: United States
DOI: 10.1093/gerona/glq094
PMID: 20530246
ISSN: 1079-5006
eISSN: 1758-535X
Language: English
Date published: 09/2010
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9983995135802771

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