Journal article
Memory suppressor genes : Inhibitory constraints on the storage of long-term memory
Science (American Association for the Advancement of Science), Vol.279(5349), pp.338-341
1998
DOI: 10.1126/science.279.5349.338
PMID: 9454331
Abstract
Synaptic plasticity, the ability of neurons to alter the strength of their synaptic connections with activity and experience, is thought to play a critical role in memory storage. Molecular studies of gene expression during long-lasting synaptic plasticity related to memory storage initially focused on the identification of positive regulators. More recent work has revealed that the establishment of long-lasting synaptic plasticity and long-term memory also requires the removal of inhibitory constraints. By analogy to tumor supressor genes, which restrain cell proliferation, we propose that these inhibitory constraints on memory storage, which restrain synapse growth, be termed memory suppressor genes.
Details
- Title: Subtitle
- Memory suppressor genes : Inhibitory constraints on the storage of long-term memory
- Creators
- Ted Abel - Columbia UniversityKelsey C Martin - Columbia UniversityDusan Bartsch - Columbia UniversityEric R Kandel - Columbia University
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.279(5349), pp.338-341
- Publisher
- American Association for the Advancement of Science; Washington, DC
- DOI
- 10.1126/science.279.5349.338
- PMID
- 9454331
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Language
- English
- Date published
- 1998
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065825002771
Metrics
34 Record Views