'Mendelian randomization' equals instrumental variable analysis with genetic instruments

George L Wehby; Robert L Ohsfeldt; Jeffrey C Murray

doi:10.1002/sim.3255

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'Mendelian randomization' equals instrumental variable analysis with genetic instruments

Journal article

Open access

Peer reviewed

'Mendelian randomization' equals instrumental variable analysis with genetic instruments

George L Wehby, Robert L Ohsfeldt and Jeffrey C Murray

Statistics in medicine, Vol.27(15), pp.2745-2749

07/10/2008

DOI: 10.1002/sim.3255

PMCID: PMC2706420

PMID: 18344186

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https://www.ncbi.nlm.nih.gov/pmc/articles/2706420View

Open Access

Abstract

Interest in instrumental variable (IV) analyses using genetic instruments has been growing over the past 4 years. The background, strength and weaknesses of this approach, which in the epidemiology literature has been referred to as 'Mendelian randomization', has been recently reviewed by Lawlor et al. (Statist. Med. 2007. DOI: 10.1002/sim.3034). We suggest a change in the nomenclature of 'Mendelian randomization' and discuss issues relevant to IV analysis including instrument validation, motivation of IV analysis and interpretation of IV estimates in order to motivate a more consistent and standard use of IV analysis across applications using genetic instruments.

Disease - etiology

Molecular Epidemiology

Epidemiologic Methods

Bias

Epidemiology - statistics & numerical data

Humans

Random Allocation

Causality

Genome, Human

Details

Title: Subtitle: 'Mendelian randomization' equals instrumental variable analysis with genetic instruments
Creators: George L Wehby - Department of Health Management and Policy, University of Iowa, E204 GH, Iowa City, IA 52242, USA. george-wehby@uiowa.edu
Robert L Ohsfeldt
Jeffrey C Murray
Resource Type: Journal article
Publication Details: Statistics in medicine, Vol.27(15), pp.2745-2749
DOI: 10.1002/sim.3255
PMID: 18344186
PMCID: PMC2706420
NLM abbreviation: Stat Med
ISSN: 0277-6715
eISSN: 1097-0258
Publisher: England
Grant note: P30 ES005605 / NIEHS NIH HHS P30 ES005605-170010 / NIEHS NIH HHS R01 HD052953-02 / NICHD NIH HHS P30 ES005605-180010 / NIEHS NIH HHS R01 DD000295 / NCBDD CDC HHS R03 DE018394 / NIDCR NIH HHS 1R01DD000295-01 / NCBDD CDC HHS R01 HD052953 / NICHD NIH HHS M01 RR000059 / NCRR NIH HHS 1R03 DE018394-01 / NIDCR NIH HHS R37 DE008559-18 / NIDCR NIH HHS R37 DE008559 / NIDCR NIH HHS R37 DE-08559 / NIDCR NIH HHS 1R01 HD-52953 / NICHD NIH HHS 2P30 EY-5605 / NEI NIH HHS M01 RR000059-466795 / NCRR NIH HHS R37 DE008559-19 / NIDCR NIH HHS R01 HD052953-03 / NICHD NIH HHS
Language: English
Date published: 07/10/2008
Academic Unit: Preventive and Community Dentistry; Anatomy and Cell Biology; Health Management and Policy; Stead Family Department of Pediatrics; Epidemiology; Economics; Pediatric Dentistry; Craniofacial Anomalies Research Center; Public Policy Center (Archive); Dental Research
Record Identifier: 9984025304202771

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