Meningoencephalitis with Aspergillus and mycobacterium tuberculosis in a renal transplant recipient

Peyman Petramfar; Marzieh Yousefian; Mohammad Hosein Ashraf; Mohammad Ali Davarpanah; Hashem Rahmati

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Meningoencephalitis with Aspergillus and mycobacterium tuberculosis in a renal transplant recipient

Journal article

Peer reviewed

Meningoencephalitis with Aspergillus and mycobacterium tuberculosis in a renal transplant recipient

Peyman Petramfar, Marzieh Yousefian, Mohammad Hosein Ashraf, Mohammad Ali Davarpanah and Hashem Rahmati

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, Vol.9(1), pp.68-71

02/2011

PMID: 21605027

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Abstract

We report a case of central nervous system coinfection with 2 types of opportunistic organisms-Aspergillus and Mycobacterium tuberculosis-in a 33-year-old woman who underwent a renal transplant. She developed a high-grade fever and right-sided weakness 1 month after the transplant while on mycophenolate mofetil, prednisolone, and cyclosporine. Brain magnetic resonance imaging revealed multiple mass lesions with peripheral ring enhancement. Colony-stimulating factor polymerase chain reaction was positive for Aspergillus and Mycobacterium tuberculosis. Broad-spectrum antibiotics, antituberculous agents, and amphotericin were started. Unfortunately, the woman's condition deteriorated, and she died 2 weeks after admission to the hospital.

Adult

Anti-Bacterial Agents - therapeutic use

Antifungal Agents - therapeutic use

Antitubercular Agents - therapeutic use

Aspergillus - genetics

Aspergillus - isolation & purification

Bacteriological Techniques

Cyclosporine - adverse effects

DNA, Bacterial - isolation & purification

DNA, Fungal - isolation & purification

Drug Therapy, Combination

Fatal Outcome

Female

Humans

Immunosuppressive Agents - adverse effects

Kidney Transplantation - adverse effects

Magnetic Resonance Imaging

Meningoencephalitis - diagnosis

Meningoencephalitis - drug therapy

Meningoencephalitis - microbiology

Mycobacterium tuberculosis - genetics

Mycobacterium tuberculosis - isolation & purification

Mycophenolic Acid - adverse effects

Mycophenolic Acid - analogs & derivatives

Polymerase Chain Reaction

Prednisolone - adverse effects

Treatment Failure

Tuberculosis, Meningeal - diagnosis

Tuberculosis, Meningeal - drug therapy

Tuberculosis, Meningeal - microbiology

Details

Title: Subtitle: Meningoencephalitis with Aspergillus and mycobacterium tuberculosis in a renal transplant recipient
Creators: Peyman Petramfar - Shiraz University of Medical Sciences
Marzieh Yousefian
Mohammad Hosein Ashraf
Mohammad Ali Davarpanah
Hashem Rahmati
Resource Type: Journal article
Publication Details: Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, Vol.9(1), pp.68-71
PMID: 21605027
NLM abbreviation: Exp Clin Transplant
ISSN: 1304-0855
eISSN: 2146-8427
Language: English
Date published: 02/2011
Academic Unit: Neurology
Record Identifier: 9985013727802771

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