Journal article
Menopause and Tear Function: The Influence of Prolactin and Sex Hormones on Human Tear Production
Cornea, Vol.17(4), pp.353-353
07/1998
DOI: 10.1097/00003226-199807000-00002
PMID: 9676904
Abstract
PURPOSEThe onset of dry eye is very common during menopause and may result from the loss of hormonal support. The purpose of this study was to assess the effect that changes in sex hormone and prolactin levels have on tear function in premenopausal and menopausal woman.
METHODSWomen between the ages of 30 and 60 were solicited to participate in a study concerning menopause and tear function. One-hundred and ten women were given tear function tests (osmolarity, tear volume, tear flow, Schirmerʼs test) and serum levels were measured for total testosterone, estradiol, prolactin, and follicle stimulating hormone.
RESULTSFor all women on hormone replacement therapy, we found a strong negative correlation between serum prolactin level and tear function. For women in menopause, total testosterone correlated positively with tear function, whereas for premenopausal women there was a negative correlation between total testosterone and tear function. Serum estradiol levels correlated positively with tear function for women 30–39 years of age, whereas for menopausal women the correlation was negative.
CONCLUSIONSThis is the first demonstration in humans that tear production is correlated with serum prolactin and sex hormone levels prior to and during the menopause.
Details
- Title: Subtitle
- Menopause and Tear Function: The Influence of Prolactin and Sex Hormones on Human Tear Production
- Creators
- William Mathers - From the Departments of Obstetrics and Gynecology (D.S., J.J.), Ophthalmology (W.D.M., J.A.L.), and Preventive Medicine (M.B.Z.), University of Iowa Hospitals and Clinics, Iowa City, Iowa, U.S.ADale StovallJames LaneM ZimmermanSusan Johnson
- Resource Type
- Journal article
- Publication Details
- Cornea, Vol.17(4), pp.353-353
- Publisher
- Lippincott-Raven Publishers
- DOI
- 10.1097/00003226-199807000-00002
- PMID
- 9676904
- ISSN
- 0277-3740
- eISSN
- 1536-4798
- Language
- English
- Date published
- 07/1998
- Academic Unit
- Epidemiology; Biostatistics; Obstetrics and Gynecology
- Record Identifier
- 9983997484902771
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