Menstrual and reproductive characteristics and breast density in young women

Joanne F Dorgan; Catherine Klifa; Snehal Deshmukh; Brian L Egleston; John A Shepherd; Peter O Kwiterovich Jr; Linda Van Horn; Linda G Snetselaar; Victor J Stevens; Alan M Robson; Norman L Lasser; Nola M Hylton

doi:10.1007/s10552-013-0273-2

Back

Menstrual and reproductive characteristics and breast density in young women

Journal article

Peer reviewed

Menstrual and reproductive characteristics and breast density in young women

Joanne F Dorgan, Catherine Klifa, Snehal Deshmukh, Brian L Egleston, John A Shepherd, Peter O Kwiterovich Jr, Linda Van Horn, Linda G Snetselaar, Victor J Stevens, Alan M Robson, …

Cancer causes & control, Vol.24(11), pp.1973-1983

11/2013

DOI: 10.1007/s10552-013-0273-2

PMCID: PMC3960004

PMID: 23933948

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/3960004View

Open Access

Abstract

Breast density is strongly related to breast cancer risk, but determinants of breast density in young women remain largely unknown. Associations of reproductive and menstrual characteristics with breast density measured by magnetic resonance imaging were evaluated in a cross-sectional study of 176 healthy women, 25-29 years old, using linear mixed effects models. Parity was significantly inversely associated with breast density. In multivariable adjusted models that included non-reproductive variables, mean percent dense breast volume (%DBV) decreased from 20.5 % in nulliparous women to 16.0 % in parous women, while mean absolute dense breast volume (ADBV) decreased from 85.3 to 62.5 cm(3). Breast density also was significantly inversely associated with the age women started using hormonal contraceptives, whereas it was significantly positively associated with duration of hormonal contraceptive use. In adjusted models, mean %DBV decreased from 21.7 % in women who started using hormones at 12-17 years of age to 14.7 % in those who started using hormones at 22-28 years of age, while mean ADBV decreased from 86.2 to 53.7 cm(3). The age at which women started using hormonal contraceptives and duration of hormone use were inversely correlated, and mean %DBV increased from 15.8 % in women who used hormones for not more than 2.0 years to 22.0 % in women who used hormones for more than 8 years, while mean ADBV increased from 61.9 to 90.4 cm(3) over this interval. Breast density in young women is inversely associated with parity and the age women started using hormonal contraceptives but positively associated with duration of hormone use.

Multivariate Analysis

Age Factors

Cross-Sectional Studies

Follow-Up Studies

Menstruation - physiology

Humans

Contraceptives, Oral, Hormonal - administration & dosage

Magnetic Resonance Imaging - methods

Reproduction - physiology

Breast Neoplasms - prevention & control

Contraception - utilization

Breast - anatomy & histology

Time Factors

Menarche - physiology

Adult

Female

Surveys and Questionnaires

Breast Neoplasms - diagnosis

Details

Title: Subtitle: Menstrual and reproductive characteristics and breast density in young women
Creators: Joanne F Dorgan - University of Maryland School of Medicine, 660 W. Redwood St., Baltimore, MD, 21201, USA, jdorgan@som.umaryland.edu
Catherine Klifa
Snehal Deshmukh
Brian L Egleston
John A Shepherd
Peter O Kwiterovich Jr
Linda Van Horn
Linda G Snetselaar
Victor J Stevens
Alan M Robson
Norman L Lasser
Nola M Hylton
Resource Type: Journal article
Publication Details: Cancer causes & control, Vol.24(11), pp.1973-1983
DOI: 10.1007/s10552-013-0273-2
PMID: 23933948
PMCID: PMC3960004
NLM abbreviation: Cancer Causes Control
ISSN: 0957-5243
eISSN: 1573-7225
Publisher: Netherlands
Grant note: R01CA104670 / NCI NIH HHS R01 CA116182 / NCI NIH HHS R01 CA104670 / NCI NIH HHS R01CA116182 / NCI NIH HHS
Language: English
Date published: 11/2013
Academic Unit: Epidemiology; Internal Medicine
Record Identifier: 9983995117302771

Metrics

19 Record Views

26 Times Cited - Web of Science