Journal article
Menstrual hormone-induced cyclic thumb CMC instability and degeneration in women: a systematic review
Biology of sex differences, Vol.13(1), pp.1-32
06/20/2022
DOI: 10.1186/s13293-022-00438-y
PMCID: PMC9208132
PMID: 35725646
Abstract
It is widely recognized among hand surgeons that female patients present at a younger age for basal thumb osteoarthritis, with more severe degeneration.
The little-known menstrual hormone relaxin, which peaks every ovulatory cycle, may be responsible for the female predominance of this pathology.
The soft tissue support structures for the thumb are known to express relaxin receptors which, when activated, trigger lysis of collagen and other extracellular matrix components.
Laxity in soft tissues supporting the thumb, such as the deep anterior oblique ligament, would result in joint instability and microtrauma.
If women cyclically experience thumb instability and cumulative cartilage microtrauma from menarche through menopause, the female propensity to develop TMC arthritis is aptly justified.
Details
- Title: Subtitle
- Menstrual hormone-induced cyclic thumb CMC instability and degeneration in women: a systematic review
- Creators
- Emily A. Parker - University of IowaAlex M. Meyer - University of Iowa Hospitals and ClinicsIgnacio Garcia Fleury - 200 Hawkins Drive, Iowa, IA 52242 USAJoseph A. Buckwalter - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Biology of sex differences, Vol.13(1), pp.1-32
- DOI
- 10.1186/s13293-022-00438-y
- PMID
- 35725646
- PMCID
- PMC9208132
- NLM abbreviation
- Biol Sex Differ
- ISSN
- 2042-6410
- eISSN
- 2042-6410
- Publisher
- BioMed Central
- Language
- English
- Date published
- 06/20/2022
- Academic Unit
- Orthopedics and Rehabilitation; Injury Prevention Research Center
- Record Identifier
- 9984627302602771
Metrics
5 Record Views