Journal article
Mepolizumab-Induced Posterior Reversible Encephalopathy Syndrome (PRES), a new patient report
BMC neurology, Vol.22(1), pp.1-318
08/25/2022
DOI: 10.1186/s12883-022-02849-1
PMCID: PMC9404554
PMID: 36008800
Abstract
Background Posterior Reversible Encephalopathy Syndrome (PRES) is a neurotoxic state characterized by seizures, headache, vision change, paresis, and altered mental status. PRES has an important place in medicine due to the wide variety of causative diseases, infections, and medications that precipitate its mysterious onset. Although exposure to medications, particularly immunosuppressants, cancer chemotherapy, and biologic drugs, is a common occurrence in patients who develop PRES, Mepolizumab has never before been associated. Case presentation This report of a 67-year-old male patient outlines the first reported case of Mepolizumab-induced PRES in the literature. Conclusions Treatment of severe asthma, asthma-exacerbations, and diseases such as eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss) with Mepolizumab is rapidly gaining popularity ever since the drug's recent FDA-approval. This report aims to raise awareness of this potentially life-threatening and previously unreported side effect of Mepolizumab since early identification of the causative agent is the key to preventing the severe neurologic disability and possible death that may occur from the delayed treatment of PRES.
Details
- Title: Subtitle
- Mepolizumab-Induced Posterior Reversible Encephalopathy Syndrome (PRES), a new patient report
- Creators
- Vikram V. Puram - University of Minnesota Medical CenterDana Ghazaleh - University of IowaApameh Salari - University of MinnesotaKaci McCleary - University of MinnesotaGerald Moriarty - University of MinnesotaKendall Nichols - University of MinnesotaMalik Ghannam - University of IowaKevin Brown - University of MinnesotaBrent Berry - University of Minnesota
- Resource Type
- Journal article
- Publication Details
- BMC neurology, Vol.22(1), pp.1-318
- Publisher
- Springer Nature
- DOI
- 10.1186/s12883-022-02849-1
- PMID
- 36008800
- PMCID
- PMC9404554
- ISSN
- 1471-2377
- eISSN
- 1471-2377
- Number of pages
- 5
- Grant note
- University of Minnesota Department of Neurology
- Language
- English
- Date published
- 08/25/2022
- Academic Unit
- Neurology
- Record Identifier
- 9984585425902771
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