Merging genetic and environmental effects in the Iowa Adoption Studies: focus on depression

Robert Philibert

doi:10.1080/10401230600948399

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Merging genetic and environmental effects in the Iowa Adoption Studies: focus on depression

Journal article

Peer reviewed

Merging genetic and environmental effects in the Iowa Adoption Studies: focus on depression

Robert Philibert

Annals of clinical psychiatry, Vol.18(4), pp.219-222

10/2006

DOI: 10.1080/10401230600948399

PMID: 17162620

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Abstract

It is generally acknowledged that the vast majority of serious mental disorders have significant genetic contributions that manifest complex inheritance patterns. Despite this, few gene polymorphisms have been unambiguously identified as risk factors for behavioral illness and the mechanisms through which these select polymorphisms affect human behavior is completely unclear. One of the major reasons for this lack of progress is the phenomenon of gene-environment (GxE) interactions. We review prior evidence of GxE interactions for major depressive disorder (MDD) in the Iowa Adoption Studies. The results demonstrate the usefulness of these cohorts to direct G effects for MDD. We conclude that further use of the adoption paradigm will generate critical insight into the effects of candidate genes for a variety of complex human behavioral illnesses.

Genetic Predisposition to Disease - genetics

Antisocial Personality Disorder - psychology

Humans

Risk Factors

Adoption - psychology

Genotype

Social Environment

Depressive Disorder, Major - psychology

Antisocial Personality Disorder - genetics

Iowa

Receptors, Thyroid Hormone - genetics

Depressive Disorder, Major - genetics

Alcoholism - genetics

Polymorphism, Genetic - genetics

Mediator Complex

Alcoholism - psychology

Cohort Studies

Details

Title: Subtitle: Merging genetic and environmental effects in the Iowa Adoption Studies: focus on depression
Creators: Robert Philibert - University of lowa, lowa City, IA 52242-1000, USA. robertphilibert@uiowa.edu
Resource Type: Journal article
Publication Details: Annals of clinical psychiatry, Vol.18(4), pp.219-222
DOI: 10.1080/10401230600948399
PMID: 17162620
NLM abbreviation: Ann Clin Psychiatry
ISSN: 1040-1237
eISSN: 1547-3325
Publisher: United States
Grant note: DA015789-01 / NIDA NIH HHS K08MH064714 / NIMH NIH HHS
Language: English
Date published: 10/2006
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984003432602771

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