Mesenchymal lineage precursor cells induce vascular network formation in ischemic myocardium

Timothy P Martens; Fiona See; Michael D Schuster; Hugo P Sondermeijer; Marco M Hefti; Andrew Zannettino; Stan Gronthos; Tetsunori Seki; Silviu Itescu

doi:10.1038/ncpcardio0404

Journal article

Mesenchymal lineage precursor cells induce vascular network formation in ischemic myocardium

Timothy P Martens, Fiona See, Michael D Schuster, Hugo P Sondermeijer, Marco M Hefti, Andrew Zannettino, Stan Gronthos, Tetsunori Seki and Silviu Itescu

Nature clinical practice cardiovascular medicine, Vol.3 Suppl 1(1), pp.S18-S22

03/2006

DOI: 10.1038/ncpcardio0404

PMID: 16501624

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Abstract

Mesenchymal lineage precursors can be reproducibly isolated from adult mammalian bone marrow and grown in culture. Immunoselection with monoclonal antibodies against STRO-1 and vascular-cell-adhesion molecule 1 (VCAM1/CD106) prior to expansion results in a 1,000-fold enrichment of mesenchymal precursors compared to standard isolation techniques. Intramyocardial injection of human STRO-1-selected precursors in an athymic rat model of acute myocardial infarction results in induction of vascular network formation and arteriogenesis coupled with global functional cardiac recovery.

Coronary Circulation

Cell Proliferation

Humans

Cells, Cultured

GPI-Linked Proteins

Rats

Rats, Nude

Mesenchymal Stromal Cells - immunology

Antigens, CD - analysis

Cell Lineage

Mesenchymal Stromal Cells - cytology

Animals

Immunomagnetic Separation

ADP-ribosyl Cyclase - analysis

Bone Marrow Cells - immunology

Myocardial Ischemia - therapy

Myocardial Ischemia - physiopathology

Hemodynamics

Vascular Cell Adhesion Molecule-1 - analysis

Mesenchymal Stem Cell Transplantation

Neovascularization, Physiologic

Disease Models, Animal

Details

Title: Subtitle: Mesenchymal lineage precursor cells induce vascular network formation in ischemic myocardium
Creators: Timothy P Martens - Division of Cardiothoracic Surgery, Columbia University, New York, NY, USA. tpm2102@columbia.edu
Fiona See
Michael D Schuster
Hugo P Sondermeijer
Marco M Hefti
Andrew Zannettino
Stan Gronthos
Tetsunori Seki
Silviu Itescu
Resource Type: Journal article
Publication Details: Nature clinical practice cardiovascular medicine, Vol.3 Suppl 1(1), pp.S18-S22
Publisher: England
DOI: 10.1038/ncpcardio0404
PMID: 16501624
ISSN: 1743-4297
eISSN: 1743-4300
Language: English
Date published: 03/2006
Academic Unit: Pathology; Iowa Neuroscience Institute
Record Identifier: 9984047743702771

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