Journal article
Meta-Analysis Evaluating Calcium Channel Blockers and the Risk of Peripheral Arterial Disease in Patients With Hypertension
The American journal of cardiology, Vol.125(6), pp.907-915
03/15/2020
DOI: 10.1016/j.amjcard.2019.12.026
PMID: 31959429
Abstract
Clinical studies have shown that calcium channel blockers (CCB) can mitigate the progression of atherosclerosis. Their role in the primary prevention of peripheral artery disease (PAD) is unclear. We conducted a meta-analysis of randomized control trials (RCT) to compare the impact of CCB on the incidence of PAD in patients with hypertension. A comprehensive review of the literature was performed in PubMed and Cochrane registry. Studies were included if they were RCT and had outcome data on PAD with a follow-up duration of at least 6 months. CCB formed the intervention group, whereas the control group was constituted by either placebo or active treatment with any of the other antihypertensive medications. A random-effects meta-analysis was performed, and we report odds ratio as a measure of treatment effect. Our search identified 934 trials, of which 7 RCTs with 71,971 patients fulfilled the inclusion criteria. The mean duration of follow-up was 3.8 years. In patients receiving CCB, PAD events occurred in 547 out of 27,502 patients (2%) compared with 1,263 out of 42,659 patients in the control group (3%). Based on the random-effect model, the odds for development of PAD in hypertensive patients treated with CCB compared with the control group was 0.70 (95% confidence interval of 0.58 to 0.86, p = 0.0005). In conclusion, this meta-analysis of RCTs of hypertensive patients, we found that treatment with CCB was strongly associated with a decrease in the PAD compared with other antihypertensive agents or placebo. (C) 2019 Elsevier Inc. All rights reserved.
Details
- Title: Subtitle
- Meta-Analysis Evaluating Calcium Channel Blockers and the Risk of Peripheral Arterial Disease in Patients With Hypertension
- Creators
- Suchith Shetty - Roy J. and Lucille A. Carver College of MedicineAaqib H. Malik - Westchester Medical CenterHerman Feringa - Cheyenne Reg Med Ctr, Dept Internal Med, Cheyenne, WY USARamzi El Accaoui - Roy J. and Lucille A. Carver College of MedicineSaket Girotra - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- The American journal of cardiology, Vol.125(6), pp.907-915
- Publisher
- Elsevier
- DOI
- 10.1016/j.amjcard.2019.12.026
- PMID
- 31959429
- ISSN
- 0002-9149
- eISSN
- 1879-1913
- Number of pages
- 9
- Language
- English
- Date published
- 03/15/2020
- Academic Unit
- Radiology; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984318713902771
Metrics
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