Meta-analysis of desflurane and propofol average times and variability in times to extubation and following commands

Ruth E Wachtel; Franklin Dexter; Richard H Epstein; Johannes Ledolter

doi:10.1007/s12630-011-9519-1

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Meta-analysis of desflurane and propofol average times and variability in times to extubation and following commands

Journal article

Open access

Peer reviewed

Meta-analysis of desflurane and propofol average times and variability in times to extubation and following commands

Ruth E Wachtel, Franklin Dexter, Richard H Epstein and Johannes Ledolter

Canadian journal of anaesthesia = Journal canadien d'anesthesie, Vol.58(8), pp.714-724

08/2011

DOI: 10.1007/s12630-011-9519-1

PMID: 21630118

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Abstract

We performed a meta-analysis to compare the operating room recovery time of desflurane with that of propofol. Studies were included in which a) humans were assigned randomly to propofol or desflurane groups without other differences between groups (e.g., induction drugs) and b) mean and standard deviation were reported for extubation time and/or time to follow commands. Since there was heterogeneity of variance between treatment groups in the log-scale (i.e., unequal coefficients of variation of observations in the time scale), generalized pivotal methods for the lognormal distribution were used as inputs of the random effects meta-analyses. Desflurane reduced the variability (i.e., standard deviation) in time to extubation by 26% relative to propofol (95% confidence interval [CI], 6% to 42%; P = 0.006) and reduced the variability in time to follow commands by 39% (95% CI, 25% to 51%; P < 0.001). Desflurane reduced the mean time to extubation by 21% (95% CI, 9% to 32%; P = 0.001) and reduced the mean time to follow commands by 23% (95% CI, 16% to 30%; P < 0.001). The mean reduction in operating room recovery time for desflurane relative to propofol was comparable with that shown previously for desflurane relative to sevoflurane. The reduction in variability exceeded that of sevoflurane. Facilities can use the percentage differences when making evidence-based pharmacoeconomic decisions.

Anesthetics, Inhalation - pharmacology

Device Removal

Anesthetics, Intravenous - pharmacology

Isoflurane - pharmacology

Time Factors

Humans

Anesthesia Recovery Period

Propofol - pharmacology

Methyl Ethers - pharmacology

Intubation, Intratracheal

Isoflurane - analogs & derivatives

Randomized Controlled Trials as Topic

Details

Title: Subtitle: Meta-analysis of desflurane and propofol average times and variability in times to extubation and following commands
Creators: Ruth E Wachtel - Department of Anesthesia, University of Iowa, Iowa City, USA
Franklin Dexter
Richard H Epstein
Johannes Ledolter
Resource Type: Journal article
Publication Details: Canadian journal of anaesthesia = Journal canadien d'anesthesie, Vol.58(8), pp.714-724
DOI: 10.1007/s12630-011-9519-1
PMID: 21630118
NLM abbreviation: Can J Anaesth
ISSN: 0832-610X
eISSN: 1496-8975
Publisher: United States
Language: English
Date published: 08/2011
Academic Unit: Statistics and Actuarial Science; Health Management and Policy; Anesthesia; Business Analytics
Record Identifier: 9983806246402771

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