Journal article
Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia
Nature communications, Vol.7(1), pp.10933-10933
2016
DOI: 10.1038/ncomms10933
PMCID: PMC4786871
PMID: 26956414
Abstract
Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P = 2.55 x 10(-11)), 6p25.2 (rs73718779, SERPINB6, P = 1.97 x 10(-8)) and 3q28 (rs9815073, LPP, P = 3.62 x 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P = 1.00 x 10(-11)) in the combined analysis. We find suggestive evidence (P<5 x 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P = 7.19 x 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P = 2.12 x 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.
Details
- Title: Subtitle
- Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia
- Creators
- Sonja I. Berndt - National Institutes of HealthNicola J. Camp - University of UtahChristine F. Skibola - University of Alabama at BirminghamJoseph Vijai - Memorial Sloan Kettering Cancer CenterZhaoming Wang - National Institutes of HealthJian Gu - The University of Texas MD Anderson Cancer CenterAlexandra Nieters - University of FreiburgRachel S. Kelly - Imperial College LondonKarin E. Smedby - Karolinska InstitutetAlain Monnereau - Délégation Paris 5Wendy Cozen - University of Southern CaliforniaAngela Cox - University of SheffieldSophia S. Wang - City Of Hope National Medical CenterQing Lan - National Institutes of HealthLauren R. Teras - American Cancer SocietyMoara Machado - Universidade Federal de Minas GeraisMeredith Yeager - National Institutes of HealthAngela R. Brooks-Wilson - Simon Fraser UniversityPatricia Hartge - National Institutes of HealthMark P. Purdue - Ontario Hlth Study, Toronto, ON M5G 0A3, CanadaBrenda M. Birmann - Harvard UniversityClaire M. Vajdic - UNSW SydneyPierluigi Cocco - University of CagliariYawei Zhang - Yale UniversityGraham G. Giles - The University of MelbourneAnne Zeleniuch-Jacquotte - New York UniversityCharles Lawrence - Westat (United States)Rebecca Montalvan - Westat (United States)Laurie Burdett - National Institutes of HealthAmy Hutchinson - National Institutes of HealthYuanqing Ye - The University of Texas MD Anderson Cancer CenterTimothy G. Call - Mayo ClinicTait D. Shanafelt - Mayo Clinic in FloridaAnne J. Novak - Mayo ClinicNeil E. Kay - Mayo ClinicMark Liebow - Mayo Clinic in FloridaJulie M. Cunningham - Mayo Clinic in FloridaCristine Allmer - Mayo Clinic in FloridaHenrik Hjalgrim - Statens Serum InstitutHans-Olov Adami - Karolinska InstitutetMads Melbye - Stanford UniversityBengt Glimelius - Uppsala UniversityEllen T. Chang - Exponent (United States)Martha Glenn - University of UtahKaren Curtin - University of UtahLisa A. Cannon-Albright - University of UtahW. Ryan Diver - American Cancer SocietyBrian K. Link - University of IowaGeorge J. Weiner - University of IowaLucia Conde - University of Alabama at BirminghamPaige M. Bracci - University of California, San FranciscoJacques Riby - University of Alabama at BirminghamDonna K. Arnett - University of Alabama at BirminghamDegui Zhi - University of Alabama at BirminghamJustin M. Leach - University of Alabama at BirminghamElizabeth A. Holly - University of California, San FranciscoRebecca D. Jackson - The Ohio State UniversityLesley F. Tinker - Fred Hutch Cancer CenterYolanda Benavente - Universitat de BarcelonaNuria Sala - Universitat de BarcelonaDelphine CasabonneNikolaus Becker - German Cancer Research CenterPaolo Boffetta - Icahn School of Medicine at Mount SinaiPaul Brennan - Centre international de recherche sur le cancerLenka ForetovaMarc Maynadie - Université de BourgogneJames McKay - Centre international de recherche sur le cancerAnthony Staines - Dublin City UniversityKari G. Chaffee - Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USASara J. Achenbach - Mayo ClinicCeline M. Vachon - Mayo ClinicLynn R. Goldin - National Institutes of HealthSara S. Strom - The University of Texas MD Anderson Cancer CenterJose F. Leis - Mayo ClinicJ. Brice Weinberg - Duke UniversityNeil E. Caporaso - National Institutes of HealthAaron D. Norman - Mayo ClinicAnneclaire J. De Roos - Drexel UniversityLindsay M. Morton - National Institutes of HealthRichard K. Severson - Wayne State UniversityElio Riboli - Imperial College LondonPaolo Vineis - Imperial College LondonRudolph Kaaks - German Cancer Research CenterGiovanna Masala - Florence (Netherlands)Elisabete WeiderpassMaria-Dolores ChirlaqueRoel C. H. VermeulenRuth C. Travis - University of OxfordMelissa C. Southey - The University of MelbourneRoger L. Milne - The University of MelbourneDemetrius Albanese - NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USAJarmo Virtamo - Finnish Institute for Health and WelfareStephanie Weinstein - National Institutes of HealthJacqueline Clavel - Délégation Paris 5Tongzhang Zheng - Yale UniversityTheodore R. Holford - Yale UniversityDanylo J. Villano - Memorial Sloan Kettering Cancer CenterAnn Maria - Memorial Sloan Kettering Cancer CenterJohn J. Spinelli - University of British ColumbiaRandy D. Gascoyne - University of British ColumbiaJoseph M. Connors - University of British ColumbiaKimberly A. Bertrand - Harvard UniversityEdward Giovannucci - Harvard UniversityPeter Kraft - Harvard UniversityAnne Kricker - The University of SydneyJenny Turner - Macquarie UniversityMaria Grazia Ennas - University of CagliariGiovanni M. Ferri - University of Bari Aldo MoroLucia Miligi - Florence (Netherlands)Liming Liang - Harvard UniversityBaoshan Ma - Dalian Maritime UniversityJinyan Huang - Harvard UniversitySimon Crouch - University of YorkJu-Hyun Park - Dongguk UniversityNilanjan Chatterjee - National Institutes of HealthKari E. North - University of North Carolina at Chapel HillJohn A. Snowden - University of SheffieldJosh Wright - University of SheffieldJoseph F. Fraumeni - National Institutes of HealthKenneth Offit - Memorial Sloan Kettering Cancer CenterXifeng Wu - The University of Texas MD Anderson Cancer CenterSilvia de Sanjose - Universitat de BarcelonaJames R. Cerhan - Mayo Clinic in FloridaStephen J. Chanock - National Institutes of HealthNathaniel Rothman - National Institutes of HealthSusan L. Slager - Mayo Clinic in Florida
- Resource Type
- Journal article
- Publication Details
- Nature communications, Vol.7(1), pp.10933-10933
- DOI
- 10.1038/ncomms10933
- PMID
- 26956414
- PMCID
- PMC4786871
- NLM abbreviation
- Nat Commun
- ISSN
- 2041-1723
- eISSN
- 2041-1723
- Language
- English
- Date published
- 2016
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Pharmaceutical Sciences and Experimental Therapeutics; Internal Medicine
- Record Identifier
- 9984359887802771
Metrics
17 Record Views