Journal article
Meta-analysis: pesticides and orofacial clefts
The Cleft palate-craniofacial journal, Vol.44(4), pp.358-365
07/2007
DOI: 10.1597/06-100.1
PMID: 17608552
Abstract
The risk of orofacial clefts associated with pesticide exposure was examined by conducting a meta-analysis of studies published from 1966 through 2005.
The full text of 230 studies was reviewed in detail, and of these, 19 studies were included in the final analysis. Fixed effects and random effects models were used to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs), and homogeneity among studies was evaluated.
Exposure- and phenotype-specific risks associated with pesticides.
Many of the studies identified as suitable for analysis used a retrospective design with varying sample sizes, levels of exposure assessment, and phenotype evaluation. For all phenotypes combined, maternal occupational exposure was associated with an increased risk of clefting (OR=1.37; CI=1.04 to 1.81), whereas the estimates were somewhat weaker for paternal occupational exposures (OR=1.16; CI=0.94 to 1.44) or for any residential exposure (OR=0.77; CI=0.20 to 2.96). Calculation of pooled estimates for individual cleft phenotypes was mostly limited to studies of paternal occupational exposure; estimates exceeded unity but were not statistically significant.
The results of this meta-analysis suggest that maternal exposure to pesticides is associated with a modest but marginally significant risk of clefting. To better understand the relationship between pesticide exposure and orofacial clefts, future studies should consider evaluation of multiple routes of parental exposure, etiologically homogenous phenotypes, and individual genetic susceptibility.
Details
- Title: Subtitle
- Meta-analysis: pesticides and orofacial clefts
- Creators
- Paul A Romitti - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City 52242, USA. paul-romitti@uiowa.eduAnna M HerringLeslie K DennisDonna L Wong-Gibbons
- Resource Type
- Journal article
- Publication Details
- The Cleft palate-craniofacial journal, Vol.44(4), pp.358-365
- Publisher
- United States
- DOI
- 10.1597/06-100.1
- PMID
- 17608552
- ISSN
- 1055-6656
- eISSN
- 1545-1569
- Grant note
- R37 DE-08559 / NIDCR NIH HHS U50/CCU 713238 / PHS HHS
- Language
- English
- Date published
- 07/2007
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9983995169302771
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