Metabolic Abnormalities in the Basal Ganglia and Cerebellum in Bipolar Disorder: A Multi-modal MR Study

Vincent A Magnotta; Jia Xu; Jess G Fiedorowicz; Aislinn Williams; Joseph Shaffer; Gary Christensen; Jeffrey D Long; Eric Taylor; Leela Sathyaputri; Jenny Gringer Richards; Gail Harmata; John Wemmie

doi:10.1016/j.jad.2022.01.052

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Metabolic Abnormalities in the Basal Ganglia and Cerebellum in Bipolar Disorder: A Multi-modal MR Study

Journal article

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Metabolic Abnormalities in the Basal Ganglia and Cerebellum in Bipolar Disorder: A Multi-modal MR Study

Vincent A Magnotta, Jia Xu, Jess G Fiedorowicz, Aislinn Williams, Joseph Shaffer, Gary Christensen, Jeffrey D Long, Eric Taylor, Leela Sathyaputri, Jenny Gringer Richards, …

Journal of affective disorders, Vol.301, pp.390-399

01/11/2022

DOI: 10.1016/j.jad.2022.01.052

PMCID: PMC8828710

PMID: 35031333

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https://www.ncbi.nlm.nih.gov/pmc/articles/8828710View

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Abstract

Bipolar type I disorder (BD) is characterized by severe mood swings and occurs in about 1% of the population. The mechanisms underlying the disorder remain unknown. Prior studies have suggested abnormalities in brain metabolism using H and P magnetic resonance spectroscopy (MRS). Supporting altered metabolism, in previous studies we found T1ρ relaxation times in the cerebellum were elevated in participants with BD. In addition, T1ρ relaxation times in the basal ganglia were lower in participants with BD experiencing depressed mood. Based on these findings, this study sought to probe brain metabolism with a focus of extending these assessments to the cerebellum. This study collected data from 64 participants with Bipolar type I disorder (BD) and 42 controls. Subjects were scanned at both 3T (anatomical, functional, and T1ρ imaging data) and 7T ( P and H spectroscopy). Regions of interest defined by the 1H MRS data were used to explore metabolic and functional changes in the cerebellar vermis and putamen. Elevated concentrations of n-Acetyl-L-aspartate (NAA), glutamate, glutathione, taurine, and creatine were found in the cerebellar vermis along with decreased intra-cellular pH. Similar trends were observed in the right putamen for glutamate, creatine, and pH. We also observed a relationship between T1ρ relaxation times and mood in the putamen. We did not observe a significant effect of medications on these measures. The study was cross sectional in design and employed a naturalistic approach for assessing the impact of medications on the results. This study supports prior findings of reduced pH in mitochondrial dysfunction in BD while also showing that these differences extend to the cerebellum.

Cerebellum

MR Spectroscopy

Bipolar disorder

Basal Ganglia

Brain Metabolism

Details

Title: Subtitle: Metabolic Abnormalities in the Basal Ganglia and Cerebellum in Bipolar Disorder: A Multi-modal MR Study
Creators: Vincent A Magnotta - Department of Radiology, The University of Iowa; Department of Psychiatry, The University of Iowa; Department of Biomedical Engineering, The University of Iowa. Electronic address: vincent-magnotta@uiowa.edu
Jia Xu - Department of Radiology, The University of Iowa
Jess G Fiedorowicz - University of Ottawa, Ottawa Hospital Research Institute
Aislinn Williams - Department of Psychiatry, The University of Iowa
Joseph Shaffer - Department of Radiology, The University of Iowa; College of Biosciences, Kansas City University
Gary Christensen - Department of Electrical and Computer Engineering, The University of Iowa; Department of Radiation Oncology, The University of Iowa
Jeffrey D Long - Department of Psychiatry, The University of Iowa; Department of Biostatistics, The University of Iowa
Eric Taylor - Department of Molecular Physiology and Biophysics, The University of Iowa
Leela Sathyaputri - Department of Radiology, The University of Iowa
Jenny Gringer Richards - Department of Radiology, The University of Iowa
Gail Harmata - Department of Psychiatry, The University of Iowa
John Wemmie - Department of Psychiatry, The University of Iowa; Department of Molecular Physiology and Biophysics, The University of Iowa; Department of Neurosurgery, The University of Iowa
Resource Type: Journal article
Publication Details: Journal of affective disorders, Vol.301, pp.390-399
DOI: 10.1016/j.jad.2022.01.052
PMID: 35031333
PMCID: PMC8828710
NLM abbreviation: J Affect Disord
ISSN: 0165-0327
eISSN: 1573-2517
Language: English
Date published: 01/11/2022
Academic Unit: Electrical and Computer Engineering; Psychiatry; Iowa Technology Institute; Biostatistics; Surgery; Radiation Research Laboratory; Advanced Pulmonary Physiomic Imaging Laboratory; Roy J. Carver Department of Biomedical Engineering; Radiology; Molecular Physiology and Biophysics; Epidemiology; Iowa Neuroscience Institute; Radiation Oncology; The Iowa Institute for Biomedical Imaging; Fraternal Order of Eagles Diabetes Research Center; Neurosurgery; Holden Comprehensive Cancer Center
Record Identifier: 9984209491702771

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