Journal article
Metabolic Messengers: FGF21
Nature metabolism, Vol.3(3), pp.309-317
03/2021
DOI: 10.1038/s42255-021-00354-2
PMCID: PMC8620721
PMID: 33758421
Abstract
As a non-canonical fibroblast growth factor, fibroblast growth factor 21 (FGF21) functions as an endocrine hormone that signals to distinct targets throughout the body. Interest in therapeutic applications for FGF21 was initially sparked by its ability to correct metabolic dysfunction and decrease body weight associated with diabetes and obesity. More recently, new functions for FGF21 signalling have emerged, thus indicating that FGF21 is a dynamic molecule capable of regulating macronutrient preference and energy balance. Here, we highlight the major physiological and pharmacological effects of FGF21 related to nutrient and energy homeostasis and summarize current knowledge regarding FGF21’s pharmacodynamic properties. In addition, we provide new perspectives and highlight critical unanswered questions surrounding this unique metabolic messenger.
Details
- Title: Subtitle
- Metabolic Messengers: FGF21
- Creators
- Kyle H Flippo - Iowa Neurosciences Institute, University of Iowa Carver College of Medicine, Iowa City, IA, USAMatthew J Potthoff - Department of Veterans Affairs Medical Center, Iowa City, IA, USA. matthew-potthoff@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Nature metabolism, Vol.3(3), pp.309-317
- DOI
- 10.1038/s42255-021-00354-2
- PMID
- 33758421
- PMCID
- PMC8620721
- NLM abbreviation
- Nat Metab
- ISSN
- 2522-5812
- eISSN
- 2522-5812
- Publisher
- Germany
- Grant note
- R01 DK106104 / NIDDK NIH HHS T32 HL007121 / NHLBI NIH HHS R01 AA027654 / NIAAA NIH HHS T32 DK112751 / NIDDK NIH HHS
- Language
- English
- Date published
- 03/2021
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984070443202771
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