Metabolic Messengers: ceramides

Scott A Summers; Bhagirath Chaurasia; William L Holland

doi:10.1038/s42255-019-0134-8

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Journal article

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Peer reviewed

Metabolic Messengers: ceramides

Scott A Summers, Bhagirath Chaurasia and William L Holland

Nature metabolism, Vol.1(11), pp.1051-1058

11/2019

DOI: 10.1038/s42255-019-0134-8

PMCID: PMC7549391

PMID: 32694860

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https://www.ncbi.nlm.nih.gov/pmc/articles/7549391View

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Abstract

Ceramides are products of metabolism that accumulate in individuals with obesity or dyslipidaemia and alter cellular processes in response to fuel surplus. Their actions, when prolonged, elicit the tissue dysfunction that underlies diabetes and heart disease. Here, we review the history of research on these enigmatic molecules, exploring their discovery and mechanisms of action, the evolutionary pressures that have given them their unique attributes and the potential of ceramide-reduction therapies as treatments for cardiometabolic disease.

Animals

Ceramides - blood

Ceramides - metabolism

Dyslipidemias - metabolism

Humans

Insulin Resistance

Obesity - metabolism

Severity of Illness Index

Signal Transduction

Details

Title: Subtitle: Metabolic Messengers: ceramides
Creators: Scott A Summers - University of Utah
Bhagirath Chaurasia - University of Utah
William L Holland - University of Utah
Resource Type: Journal article
Publication Details: Nature metabolism, Vol.1(11), pp.1051-1058
DOI: 10.1038/s42255-019-0134-8
PMID: 32694860
PMCID: PMC7549391
NLM abbreviation: Nat Metab
ISSN: 2522-5812
eISSN: 2522-5812
Grant note: R01 DK115824 / NIDDK NIH HHS P30 DK020579 / NIDDK NIH HHS R43 DK116450 / NIDDK NIH HHS R44 DK116450 / NIDDK NIH HHS R01 DK122001 / NIDDK NIH HHS
Language: English
Date published: 11/2019
Academic Unit: Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984360040402771

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