Journal article
Metabolic Pathways in Deep Vein Thrombosis: A New Frontier for Therapeutic Intervention
Blood, Vol.146(1), pp.29-40
07/03/2025
DOI: 10.1182/blood.2024027636
PMCID: PMC12290517
PMID: 40132161
Abstract
Venous thromboembolism, which includes deep vein thrombosis (DVT) and pulmonary embolism, is a common cardiovascular disorder associated with significant morbidity and mortality. Current treatment options primarily involve anticoagulants, which reduce the risk of fatal events and DVT recurrence but increase the risk of bleeding, particularly in patients requiring prolonged thromboprophylaxis. Growing evidence characterizes DVT as a complex inflammation-driven process rather than a merely coagulation-dependent thrombosis, with endothelial cells, neutrophils, and platelets playing major roles in its initiation. Recent studies demonstrate that these cell types undergo profound metabolic reprogramming in response to stasis, hypoxia, and inflammatory stimuli, including shifts in glycolysis, the pentose phosphate pathway, and redox balance. This review summarizes current insights into these metabolic adaptations, examines evidence from preclinical DVT models showing that targeting metabolic pathways can reduce venous thrombus formation without impairing hemostasis, and highlights potential metabolic targets for intervention. By modulating metabolic pathways that underlie the prothrombotic and proinflammatory phenotypes, it may be possible to prevent DVT initiation or limit its progression while reducing the reliance on anticoagulants and the risk of associated bleeding complications. This metabolism-centered perspective opens new avenues for the development of safer, more effective treatments for DVT.
Details
- Title: Subtitle
- Metabolic Pathways in Deep Vein Thrombosis: A New Frontier for Therapeutic Intervention
- Creators
- Ivan Budnik - University of IowaMariia Kumskova - University of IowaAnil Chauhan - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Blood, Vol.146(1), pp.29-40
- DOI
- 10.1182/blood.2024027636
- PMID
- 40132161
- PMCID
- PMC12290517
- NLM abbreviation
- Blood
- ISSN
- 0006-4971
- eISSN
- 1528-0020
- Publisher
- ELSEVIER
- Grant note
- National Institutes of Health (NIH), National Heart, Lung, and Blood Institute: R35HL139926 NIH, National Institute of Neurological Disorders and Stroke: U01NS130587
The A.K.C. laboratory is supported by grants from the National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (R35HL139926), and the NIH, National Institute of Neurological Disorders and Stroke (U01NS130587).
- Language
- English
- Electronic publication date
- 03/25/2025
- Date published
- 07/03/2025
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984802405402771
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