Journal article
Metabolic Stress Mitochondrial Function in Neointimal Formation
Arteriosclerosis, thrombosis, and vascular biology, Vol.39(6), pp.991-997
06/01/2019
DOI: 10.1161/ATVBAHA.118.312196
PMCID: PMC6531338
PMID: 31070466
Abstract
Mitochondria regulate major aspects of cell function by producing ATP, contributing to Ca2+ signaling, influencing redox potential, and controlling levels of reactive oxygen species. In this review, we will discuss recent findings that illustrate how mitochondrial respiration, Ca2+ handling, and production of reactive oxygen species affect vascular smooth muscle cell function during neointima formation. We will review mitochondrial fission/fusion as fundamental mechanisms for smooth muscle proliferation, migration, and metabolism and examine the role of mitochondrial mobility in cell migration. In addition, we will summarize novel aspects by which mitochondria regulate apoptosis.
Details
- Title: Subtitle
- Metabolic Stress Mitochondrial Function in Neointimal Formation
- Creators
- Isabella M. Grumbach - University of IowaEmily K. Nguyen - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Arteriosclerosis, thrombosis, and vascular biology, Vol.39(6), pp.991-997
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1161/ATVBAHA.118.312196
- PMID
- 31070466
- PMCID
- PMC6531338
- ISSN
- 1079-5642
- eISSN
- 1524-4636
- Number of pages
- 7
- Grant note
- 17GRNT33660032 / American Heart Association I01 BX000163 / Veterans Affairs Iowa City F30HL131078 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) T32GM007337 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) I01BX000163 / Veterans Affairs; US Department of Veterans Affairs R01 HL 108932; F30 HL131078-01; T32 GM007337 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 06/01/2019
- Academic Unit
- Cardiovascular Medicine; Radiation Oncology; Internal Medicine
- Record Identifier
- 9984359568202771
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