Journal article
Metabolic alterations in rabbit cerebral arteries caused by subarachnoid hemorrhage
Stroke, Vol.19(7), pp.883-887
1988
DOI: 10.1161/01.STR.19.7.883
PMID: 3388459
Abstract
The effect of subarachnoid hemorrhage on metabolic rates in rabbit cerebral arteries was investigated by measuring adenosine triphosphate (ATP) content and L-lactate release. The mean +/- SEM ATP content was 0.38 +/- 0.02 mumol/g wet wt in control rabbit basilar arteries (n = 6). The ATP content decreased significantly to 0.17 +/- 0.02 mumol/g wet wt 2 days after experimental subarachnoid hemorrhage (n = 6), although only a slight decrease was detected in the basilar arteries 2 days after cisternal injection of the same amount of artificial cerebrospinal fluid. Hypoxia significantly decreased ATP content in the control basilar arteries to 0.26 +/- 0.04 mumol/g wet wt (n = 6). The same degree of hypoxia did not decrease ATP content in the basilar arteries after subarachnoid hemorrhage. Release of L-lactate was significantly higher from the arteries after subarachnoid hemorrhage than from the control arteries under both aerobic and hypoxic conditions. Our results indicate that subarachnoid hemorrhage induced an alteration of metabolic rates in rabbit cerebral arteries. The oxygen-requiring pathways to synthesize ATP may be important in control cerebral arteries; however, after experimental subarachnoid hemorrhage, the main pathway in the cerebral arteries may shift from oxygen-requiring pathways to an anaerobic glycolytic pathway.
Details
- Title: Subtitle
- Metabolic alterations in rabbit cerebral arteries caused by subarachnoid hemorrhage
- Creators
- Tetsuya TsukaharaNeal F KassellKazuhiro HongoR. Michael LehmanJames C Torner
- Resource Type
- Journal article
- Publication Details
- Stroke, Vol.19(7), pp.883-887
- DOI
- 10.1161/01.STR.19.7.883
- PMID
- 3388459
- NLM abbreviation
- Stroke
- ISSN
- 0039-2499
- eISSN
- 1524-4628
- Language
- English
- Date published
- 1988
- Academic Unit
- Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9983996072802771
Metrics
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