Journal article
Metabolic control of transcription
Science (American Association for the Advancement of Science), Vol.381(6654), pp.125-126
07/14/2023
DOI: 10.1126/science.adi7577
Abstract
Light alters histone methylation in plants via nuclear α-ketoglutarate dehydrogenase
Mechanisms that link environmental stimuli to organismal transcriptional responses facilitate adaptation and survival. Because it signals energy availability through photosynthesis, light is among the most important environmental signals for plants. On page 179 of this issue, Huang et al. ( 1 ) demonstrate that, in the plant Arabidopsis thaliana , light exposure stimulates chromatin-local depletion of the tricarboxylic acid (TCA) cycle metabolite α-ketoglutarate to orchestrate global gene expression by impairing demethylation of nucleosomal histone tails. These findings provide a molecular mechanism for how the Arabidopsis genome senses light. They also demonstrate how subcellular metabolism can be spatially reorganized to regulate chromatin structure and transcription.
Details
- Title: Subtitle
- Metabolic control of transcription
- Creators
- Eric B. Taylor - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.381(6654), pp.125-126
- DOI
- 10.1126/science.adi7577
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Language
- English
- Date published
- 07/14/2023
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Molecular Physiology and Biophysics
- Record Identifier
- 9984445014902771
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