Journal article
Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis
Seminars in cell & developmental biology, Vol.53, pp.85-93
05/2016
DOI: 10.1016/j.semcdb.2015.09.021
PMCID: PMC4814376
PMID: 26428296
Abstract
The metabolic fibroblast growth factors (FGFs), FGF1, FGF15/19, and FGF21 differ from classic FGFs in that they modulate energy homeostasis in response to fluctuating nutrient availability. These unique mediators of metabolism regulate a number of physiological processes which contribute to their potent pharmacological properties. Administration of pharmacological doses of these FGFs causes weight loss, increases energy expenditure, and improves carbohydrate and lipid metabolism in obese animal models. However, many questions remain regarding the precise molecular and physiological mechanisms governing the effects of individual metabolic FGFs. Here we review the metabolic actions of FGF1, FGF15/19, and FGF21 while providing insights into their pharmacological effects by examining known biological functions.
Details
- Title: Subtitle
- Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis
- Creators
- Kathleen R Markan - Department of Pharmacology and University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USAMatthew J Potthoff - Department of Pharmacology and University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA. Electronic address: matthew-potthoff@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Seminars in cell & developmental biology, Vol.53, pp.85-93
- Publisher
- England
- DOI
- 10.1016/j.semcdb.2015.09.021
- PMID
- 26428296
- PMCID
- PMC4814376
- ISSN
- 1084-9521
- eISSN
- 1096-3634
- Grant note
- R01 DK106104 / NIDDK NIH HHS F32 DK102347 / NIDDK NIH HHS
- Language
- English
- Date published
- 05/2016
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology
- Record Identifier
- 9984040259602771
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